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NLRP3 蛋白

(NLR Family, Pyrin Domain Containing 3 (NLRP3))

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008].

recommended

NLRP3 Protein (AA 1-1036) (GST tag) (ABIN1312675)

NLRP3 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

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recommended

NLRP3 Protein (AA 5-218) (His-IF2DI Tag) (ABIN7124184)

NLRP3 宿主: 人宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA

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recommended

NLRP3 Protein (AA 1-100) (GST tag) (ABIN1312677)

NLRP3 宿主: 人宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

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NLRP3 蛋白 by Origin

Find NLRP3 蛋白 for a variety of species such as anti-Human NLRP3, anti-Mouse NLRP3. The species listed below are among those available. Click on a link to go to the corresponding products.

NLRP3 蛋白 by Source

Here you will find NLRP3 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

NLRP3 蛋白 by 蛋白类型

Here you can find NLRP3 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

NLRP3 蛋白 by 应用范围

Find NLRP3 蛋白 validated for a specific application such as WB, ELISA, SDS, AP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular NLRP3 蛋白

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

NLRP3 Protein (AA 1-1036) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1312675

Quantity 2 μg

Datasheet Datasheet

NLRP3 Protein (AA 5-218) (His-IF2DI Tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7124184

Quantity 50 μg

Datasheet Datasheet

NLRP3 Protein (AA 1-100) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1312677

Quantity 10 μg

Datasheet Datasheet

NLRP3 Protein (AA 2-1036) (DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN6964301

Quantity 100 μg

Datasheet Datasheet

NLRP3 Protein (AA 671-1033) (His tag)

Reactivity Mouse

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7417258

Quantity 100 μg

Datasheet Datasheet

NLRP3 Protein (AA 770-1036) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN7423546

Quantity 100 μg

Datasheet Datasheet

NLRP3 Protein (AA 1-1036) (Strep Tag)

Reactivity Human

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3094146

Quantity 1 mg

Datasheet Datasheet

NLRP3 Protein (AA 1-1033) (Strep Tag)

Reactivity Mouse

Source Tobacco (Nicotiana tabacum)

Validations

Cat. No. ABIN3136668

Quantity 1 mg

Datasheet Datasheet

Latest Publications for our NLRP3 蛋白

Shi, Wang, Li, Zhan, Tang, Fina, Su, Pratt, Bu, Hildebrand, Lyon, Scott, Quan, Sun, Russell, Arnett, Jurek, Chen, Kravchenko, Mathison, Moresco, Monson, Ulevitch, Beutler: "NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component." in: Nature immunology, Vol. 17, Issue 3, pp. 250-8, (2016) (PubMed).

He, Varadarajan, Muñoz-Planillo, Burberry, Nakamura, Núñez: "3,4-methylenedioxy-?-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome." in: The Journal of biological chemistry, Vol. 289, Issue 2, pp. 1142-50, (2014) (PubMed).

Cocco, Garella, Di Stilo, Borretto, Stevanato, Giorgis, Marini, Fantozzi, Miglio, Bertinaria: "Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis." in: Journal of medicinal chemistry, Vol. 57, Issue 24, pp. 10366-82, (2014) (PubMed).

Bruchard, Mignot, Derangère, Chalmin, Chevriaux, Végran, Boireau, Simon, Ryffel, Connat, Kanellopoulos, Martin, Rébé, Apetoh, Ghiringhelli: "Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth." in: Nature medicine, Vol. 19, Issue 1, pp. 57-64, (2013) (PubMed).

Lu, Nakamura, Inouye, Li, Tang, Lundbäck, Valdes-Ferrer, Olofsson, Kalb, Roth, Zou, Erlandsson-Harris, Yang, Ting, Wang, Andersson, Antoine, Chavan, Hotamisligil, Tracey: "Novel role of PKR in inflammasome activation and HMGB1 release." in: Nature, Vol. 488, Issue 7413, pp. 670-4, (2012) (PubMed).

Aliases for NLRP3 蛋白

NLR family pyrin domain containing-like (NLRPL) 蛋白
NLR family pyrin domain containing 3 (NLRP3) 蛋白
NLR family, pyrin domain containing 3 L homeolog (nlrp3.L) 蛋白
NLR family, pyrin domain containing 3 (Nlrp3) 蛋白
agtavprl 蛋白
AGTAVPRL 蛋白
AII 蛋白
AII/AVP 蛋白
avp 蛋白
AVP 蛋白
C1orf7 蛋白
CIAS1 蛋白
cias1 蛋白
Cias1 蛋白
CLR1.1 蛋白
FCAS 蛋白
FCU 蛋白
Mmig1 蛋白
MWS 蛋白
Nalp3 蛋白
nalp3 蛋白
NALP3 蛋白
pypaf1 蛋白
PYPAF1 蛋白
Pypaf1 蛋白

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NLRP3 蛋白 by Origin

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NLRP3 蛋白 by 蛋白类型

NLRP3 蛋白 by 应用范围

Popular NLRP3 蛋白

Latest Publications for our NLRP3 蛋白

Aliases for NLRP3 蛋白

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