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NLR Family, Pyrin Domain Containing 1B 蛋白

(NLR Family, Pyrin Domain Containing 1B (NLRP1B))
As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (By similarity). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Might be activated by Toxoplasma gondii, although at a lower extent than allele 1 (PubMed:24218483). Contrary to Nlrp1b allele 1, allele 2 is not activated by Bacillus anthracis lethal toxin (PubMed:16429160, PubMed:21170303, PubMed:24492532). {ECO:0000250|UniProtKB:Q2LKW6, ECO:0000269|PubMed:16429160, ECO:0000269|PubMed:18511561, ECO:0000269|PubMed:21170303, ECO:0000269|PubMed:24492532}.
NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-1177) protein (Strep Tag) (ABIN3130666)

NLRP1B 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant > 80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, SDS, WB

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-1196) protein (Strep Tag) (ABIN3134880)

NLRP1B 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant > 80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, SDS, WB

NLR Family, Pyrin Domain Containing 1B (NLRP1B) (AA 1-1172) protein (Strep Tag) (ABIN3134940)

NLRP1B 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant > 80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). ELISA, SDS, WB

NLR Family, Pyrin Domain Containing 1B 蛋白 by Origin

Find NLR Family, Pyrin Domain Containing 1B 蛋白 for a variety of species such as anti-Mouse NLR Family, Pyrin Domain Containing 1B. The species listed below are among those available. Click on a link to go to the corresponding products.

NLR Family, Pyrin Domain Containing 1B 蛋白 by Source

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NLR Family, Pyrin Domain Containing 1B 蛋白 by 蛋白类型

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NLR Family, Pyrin Domain Containing 1B 蛋白 by 应用范围

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Popular NLR Family, Pyrin Domain Containing 1B 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3130666
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3134880
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3134940
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3134941
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3134939
Quantity 1 mg
Datasheet Datasheet

Aliases for NLR Family, Pyrin Domain Containing 1B 蛋白

NLR family, pyrin domain containing 1B (Nlrp1b) 蛋白
Nalp1b 蛋白
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