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NFKB2 蛋白

(Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 2 (NFKB2))
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14- activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form\; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65 (By similarity).
NFKB2 Protein (AA 1-900) (Strep Tag) (ABIN3094116)

NFKB2 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant > 80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). WB, ELISA, SDS

NFKB2 Protein (AA 1-899) (Strep Tag) (ABIN3137475)

NFKB2 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant > 80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC). WB, ELISA, SDS

NFKB2 Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag) NFKB2 Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag) NFKB2 Protein (Transcript Variant 3) (Myc-DYKDDDDK Tag) (ABIN2727696)

NFKB2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD

NFKB2 蛋白 by Origin

Find NFKB2 蛋白 for a variety of species such as anti-Human NFKB2, anti-Mouse NFKB2. The species listed below are among those available. Click on a link to go to the corresponding products.

NFKB2 蛋白 by Source

Here you will find NFKB2 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

NFKB2 蛋白 by 蛋白类型

Here you can find NFKB2 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

NFKB2 蛋白 by 应用范围

Find NFKB2 蛋白 validated for a specific application such as WB, AbP, ELISA, SDS. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular NFKB2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3094116
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3137475
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2727696
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2727225
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Insect cells (Sf9)
Validations
Cat. No. ABIN6700319
Quantity 50 μg
Datasheet Datasheet

Aliases for NFKB2 蛋白

nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 (Nfkb2) 蛋白
lyt 蛋白
NF-kappaB2 蛋白
p49 蛋白
p49/p100 蛋白
p50B 蛋白
p52 蛋白
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