NFASC 产品
(Neurofascin (NFASC))
Categories
This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009].
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Featured NFASC Categories
NFASC 抗体
High quality antibodies with extensive validation data.
NFASC ELISA试剂盒
Reliable ELISA kits for a wide range of species.
NFASC 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NFASC 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), ICC, IHC (fro), IHC (p)
Validations
- (4)
Cat. No.
ABIN727325
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (3)
Cat. No.
ABIN3017267
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN524981
Quantity
50 μL
Datasheet
Datasheet
Recommended NFASC ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6958098
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1144672
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Validations
Cat. No.
ABIN1144670
Quantity
96 tests
Datasheet
Datasheet
Recommended NFASC 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7197149
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312436
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7386194
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our NFASC Products
: "Neurofilament light chain level is a weak risk factor for the development of MS. ..." in: Neurology, Vol. 87, Issue 11, pp. 1076-84, (2016) (PubMed).: "Gas6 enhances axonal ensheathment by MBP+ membranous processes in human DRG/OL promyelinating co-cultures." in: ASN neuro, Vol. 6, Issue 1, pp. e00135, (2014) (PubMed).
: "Axon initial segment cytoskeleton comprises a multiprotein submembranous coat containing sparse actin filaments." in: The Journal of cell biology, Vol. 205, Issue 1, pp. 67-81, (2014) (PubMed).
: "I?B? is not required for axon initial segment assembly." in: Molecular and cellular neurosciences, Vol. 50, Issue 1, pp. 1-9, (2012) (PubMed).
: "Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis." in: Annals of neurology, Vol. 71, Issue 5, pp. 601-13, (2012) (PubMed).
: "A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly." in: Cell, Vol. 149, Issue 5, pp. 1125-39, (2012) (PubMed).
: "Doublecortin (DCX) mediates endocytosis of neurofascin independently of microtubule binding." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 22, pp. 7439-53, (2012) (PubMed).
: "High-capacity peptide-centric platform to decode the proteomic response to brain injury." in: Electrophoresis, Vol. 33, Issue 24, pp. 3712-9, (2012) (PubMed).
: "Acrolein induces myelin damage in mammalian spinal cord." in: Journal of neurochemistry, Vol. 117, Issue 3, pp. 554-64, (2011) (PubMed).
: "Accumulation of Kv7.2 channels in putative ectopic transduction zones of mice nerve-end neuromas." in: Molecular pain, Vol. 7, pp. 58, (2011) (PubMed).
Synonyms and alternative names related to NFASC
neurofascin (NFASC), neurofascin homolog (chicken) a (nfasca), neurofascin (Nfasc), AA387016, D430023G06Rik, mKIAA0756, NF, NRCAML, sc:d0205Protein level used designations for NFASC
- neurofascin
- neurofascin homolog
- neurofascin homolog (chicken)
- neurofascin-like
- neurofascin homolog (chicken) isoform 1
- neurofascin homolog (chicken) isoform 2
- neurofascin homolog (chicken) isoform 3
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