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NEK2 产品

(NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))

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This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011].

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Featured NEK2 Categories

NEK2 抗体

High quality antibodies with extensive validation data.

NEK2 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

NEK2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended NEK2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (5)
Cat. No. ABIN7439456
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IP, IHC (p)
Validations
  • (5)
Cat. No. ABIN561955
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (4)
Cat. No. ABIN561956
Quantity 100 μg
Datasheet Datasheet

Recommended NEK2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN5525181
Quantity 96 tests
Datasheet Datasheet

Recommended NEK2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312356
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5509038
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7416697
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our NEK2 Products

Zhao, Han, Liu, Cui, Chen: "MicroRNA-128 promotes apoptosis in lung cancer by directly targeting NIMA-related kinase 2." in: Thoracic cancer, Vol. 8, Issue 4, pp. 304-311, (2018) (PubMed).

Lin, Zhou, Jiang, Liu, Wang, Zheng, Zhou, Li, Cai: "NEK2 regulates stem-like properties and predicts poor prognosis in hepatocellular carcinoma." in: Oncology reports, Vol. 36, Issue 2, pp. 853-62, (2017) (PubMed).

Zeng, Han, Wang, Cai, Huang, Luo, Liu, Zhuo, Dai, Zhao, Liang, Zhong: "Overexpression of NIMA-related kinase 2 is associated with progression and poor prognosis of prostate cancer." in: BMC urology, Vol. 15, pp. 90, (2015) (PubMed).

Zhong, Guan, Dong, Yang, Liu, Zhang: "Examining Nek2 as a better proliferation marker in non-small cell lung cancer prognosis." in: Tumour biology, Vol. 35, Issue 7, pp. 7155-62, (2014) (PubMed).

Zhong, Guan, Liu, Zhang: "Aberrant expression of NEK2 and its clinical significance in non-small cell lung cancer." in: Oncology letters, Vol. 8, Issue 4, pp. 1470-1476, (2014) (PubMed).

Naro, Barbagallo, Chieffi, Bourgeois, Paronetto, Sette: "The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival." in: Nucleic acids research, Vol. 42, Issue 5, pp. 3218-27, (2014) (PubMed).

Jeong, Lee, Park, Han, Jang, Lim, Lee, Yang: "Cancerous inhibitor of protein phosphatase 2A (CIP2A) protein is involved in centrosome separation through the regulation of NIMA (never in mitosis gene A)-related kinase 2 (NEK2) protein activity." in: The Journal of biological chemistry, Vol. 289, Issue 1, pp. 28-40, (2014) (PubMed).

van Ree, Jeganathan, Malureanu, van Deursen: "Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation." in: The Journal of cell biology, Vol. 188, Issue 1, pp. 83-100, (2010) (PubMed).

Barbagallo, Paronetto, Franco, Chieffi, Dolci, Fry, Geremia, Sette: "Increased expression and nuclear localization of the centrosomal kinase Nek2 in human testicular seminomas." in: The Journal of pathology, Vol. 217, Issue 3, pp. 431-41, (2009) (PubMed).

Wu, Baxter, Wattam, Hayward, Fardilha, Knebel, Ford, da Cruz e Silva, Fry: "Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase." in: The Journal of biological chemistry, Vol. 282, Issue 36, pp. 26431-40, (2007) (PubMed).

Synonyms and alternative names related to NEK2

NIMA related kinase 2 (NEK2), NIMA (never in mitosis gene a)-related expressed kinase 2 (Nek2), NIMA-related kinase 2 (Nek2), NIMA-related kinase 2 (NEK2), AA617254, ATNEK2, C77054, HsPK21, NEK2A, NIMA-RELATED KINASE2, NIMA-related kinase 2, NLK1, T9J14.24, T9J14_24

Protein level used designations for NEK2

  • NIMA (never in mitosis gene a)-related kinase 2
  • NIMA - related expressed kinase 2
  • NIMA-related expressed kinase 2
  • NIMA-related kinase 2
  • Nek2 kinase
  • never in mitosis A-related kinase 2
  • nimA-related protein kinase 2
  • serine/threonine-protein kinase Nek2
  • serine/threonine protein kinase Nek2
  • nimA-like protein kinase 1
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