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NCOR2 产品

(Nuclear Receptor Co-Repressor 2 (NCOR2))

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This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011].

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Featured NCOR2 Categories

NCOR2 抗体

High quality antibodies with extensive validation data.

NCOR2 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

Recommended NCOR2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (4)
Cat. No. ABIN6144422
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validations
  • (2)
Cat. No. ABIN686302
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN564153
Quantity 50 μL
Datasheet Datasheet

Recommended NCOR2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969004
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969005
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative DNA-Binding ELISA
Validations
Cat. No. ABIN5648559
Quantity 96 tests
Datasheet Datasheet

Recommended NCOR2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1312140
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our NCOR2 Products

Zhang, Gong, Lau, Yang, Wong, Cheung, Tsang, Chan, Khoo: "SpliceArray profiling of breast cancer reveals a novel variant of NCOR2/SMRT that is associated with tamoxifen resistance and control of ER? transcriptional activity." in: Cancer research, Vol. 73, Issue 1, pp. 246-55, (2013) (PubMed).

Zhou, Li, Hu, Gong, Drescher, Chen: "miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene." in: PLoS ONE, Vol. 7, Issue 1, pp. e30772, (2012) (PubMed).

Catalano, Mauro, Bonofiglio, Pellegrino, Qi, Rizza, Vizza, Bossi, Andò: "In vivo and in vitro evidence that PPARγ ligands are antagonists of leptin signaling in breast cancer." in: The American journal of pathology, Vol. 179, Issue 2, pp. 1030-40, (2011) (PubMed).

Liao, Chen, Zhang, Godavarthy, Xia, Ghosh, Li, Chen: "Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT." in: The Journal of biological chemistry, Vol. 278, Issue 7, pp. 5052-61, (2003) (PubMed).

Agoulnik, Krause, Bingman, Rahman, Amrikachi, Ayala, Weigel: "Repressors of androgen and progesterone receptor action." in: The Journal of biological chemistry, Vol. 278, Issue 33, pp. 31136-48, (2003) (PubMed).

Wu, Li, Park, Chen: "SMRTE inhibits MEF2C transcriptional activation by targeting HDAC4 and 5 to nuclear domains." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 24177-85, (2001) (PubMed).

Huang, Zhang, Miska, Guenther, Kouzarides, Lazar: "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway." in: Genes & development, Vol. 14, Issue 1, pp. 45-54, (2000) (PubMed).

Ordentlich, Downes, Xie, Genin, Spinner, Evans: "Unique forms of human and mouse nuclear receptor corepressor SMRT." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 6, pp. 2639-44, (1999) (PubMed).

Wagner, Norris, Knotts, Weigel, McDonnell: "The nuclear corepressors NCoR and SMRT are key regulators of both ligand- and 8-bromo-cyclic AMP-dependent transcriptional activity of the human progesterone receptor." in: Molecular and cellular biology, Vol. 18, Issue 3, pp. 1369-78, (1998) (PubMed).

Nagy, Kao, Chakravarti, Lin, Hassig, Ayer, Schreiber, Evans: "Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase." in: Cell, Vol. 89, Issue 3, pp. 373-80, (1997) (PubMed).

Synonyms and alternative names related to NCOR2

nuclear receptor corepressor 2 (NCOR2), nuclear receptor co-repressor 2 (Ncor2), nuclear receptor corepressor 2 (ncor2), nuclear receptor co-repressor 2 (NCOR2), CTG26, ctg26, gb:be017685, N-CoR, N-CoR2, NCOR2, si:bz71m17.2, SMAP270, SMRT, smrt, SMRTE, SMRTe, smrte, SMRTE-tau, smrte-tau, TNRC14, tnrc14, TRAC, TRAC-1, trac-1, TRAC1, trac1

Protein level used designations for NCOR2

  • CTG repeat protein 26
  • T3 receptor-associating factor
  • silencing mediator for retinoid and thyroid hormone receptors
  • thyroid-, retinoic-acid-receptor-associated corepressor
  • nuclear receptor corepressor 2
  • nuclear receptor co-repressor 2
  • N-CoR2
  • TRAC
  • silencing mediator of retinoic acid and thyroid hormone receptor
  • silencing mediator of retinoid acid and thyroid hormone receptor
  • silencing mediator
  • thyroid hormone receptor
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