NCOA2 抗体
(Nuclear Receptor Coactivator 2 (NCOA2))
The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010].
recommended
recommended
NCOA2 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马, Pig WB 宿主: 兔 Polyclonal unconjugated
recommended
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Latest Publications for our NCOA2 抗体
: "Hec1 Tail Phosphorylation Differentially Regulates Mammalian Kinetochore Coupling to Polymerizing and Depolymerizing Microtubules." in: Current biology : CB, Vol. 27, Issue 11, pp. 1692-1699.e3, (2018) (PubMed).: "Estradiol Preferentially Induces Progestin Receptor-A (PR-A) Over PR-B in Cells Expressing Nuclear Receptor Coactivators in the Female Mouse Hypothalamus(1,2,3)." in: eNeuro, Vol. 2, Issue 4, (2015) (PubMed).
: "Interaction of STAT6 with its co-activator SRC-1/NCoA-1 is regulated by dephosphorylation of the latter via PP2A." in: Nucleic acids research, Vol. 39, Issue 8, pp. 3255-66, (2011) (PubMed).
: "Nuclear receptor coactivators are coexpressed with steroid receptors and regulated by estradiol in mouse brain." in: Neuroendocrinology, Vol. 94, Issue 1, pp. 49-57, (2011) (PubMed).
: "Steroid receptor coactivator 2 modulates steroid-dependent male sexual behavior and neuroplasticity in Japanese quail (Coturnix japonica)." in: Journal of neurochemistry, Vol. 119, Issue 3, pp. 579-93, (2011) (PubMed).
: "ETV6-NCOA2: a novel fusion gene in acute leukemia associated with coexpression of T-lymphoid and myeloid markers and frequent NOTCH1 mutations." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 4, pp. 977-83, (2008) (PubMed).
: "The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus." in: The EMBO journal, Vol. 21, Issue 4, pp. 736-48, (2002) (PubMed).
: "Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene." in: Science (New York, N.Y.), Vol. 279, Issue 5358, pp. 1922-5, (1998) (PubMed).
: "A signature motif in transcriptional co-activators mediates binding to nuclear receptors." in: Nature, Vol. 387, Issue 6634, pp. 733-6, (1997) (PubMed).
: "TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors." in: The EMBO journal, Vol. 15, Issue 14, pp. 3667-75, (1996) (PubMed).
Aliases for NCOA2 抗体
nuclear receptor coactivator 2 (NCOA2) 抗体nuclear receptor coactivator 2 (Ncoa2) 抗体
nuclear receptor coactivator 2 (ncoa2) 抗体
nuclear receptor coactivator 2 (LOC100089041) 抗体
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KAT13C 抗体
kat13c 抗体
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ncoa2-A 抗体
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src2 抗体
TIF-2 抗体
TIF2 抗体
tif2 抗体
Tif2 抗体
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wu:fe26a11 抗体
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