NAE1 产品
(NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))
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The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Latest Publications for our NAE1 Products
: "PPARγ neddylation essential for adipogenesis is a potential target for treating obesity." in: Cell death and differentiation, Vol. 23, Issue 8, pp. 1296-311, (2016) (PubMed).: "More than the sum of its parts." in: Cell reports, Vol. 1, Issue 1, pp. 1, (2012) (PubMed).
: "A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924." in: Cell reports, Vol. 1, Issue 4, pp. 309-16, (2012) (PubMed).
: "Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8." in: Nature, Vol. 422, Issue 6929, pp. 330-4, (2003) (PubMed).
: "ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis." in: Journal of neurochemistry, Vol. 85, Issue 3, pp. 801-9, (2003) (PubMed).
: "APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain." in: The Journal of cell biology, Vol. 163, Issue 1, pp. 27-33, (2003) (PubMed).
: "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons." in: The Journal of biological chemistry, Vol. 275, Issue 12, pp. 8929-35, (2000) (PubMed).
: "Covalent modification of all members of human cullin family proteins by NEDD8." in: Oncogene, Vol. 18, Issue 48, pp. 6829-34, (2000) (PubMed).
: "APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein." in: The Journal of biological chemistry, Vol. 271, Issue 19, pp. 11339-46, (1996) (PubMed).
Synonyms and alternative names related to NAE1
beta-Amyloid precursor protein binding protein 1 (APP-BP1), NEDD8 activating enzyme E1 subunit 1 (NAE1), NEDD8 activating enzyme E1 subunit 1 (Nae1), NEDD8 activating enzyme E1 subunit 1 S homeolog (nae1.S), nedd8 activating enzyme E1 subunit 1 (nae1), NEDD8-activating enzyme E1 regulatory subunit (ula-1), 59kDa, A-116A10.1, anon-WO0140519.225, APPBP1, Appbp1, appbp1, CG7828, dAPP-BP1, dAPPBP1, Dmel\\CG7828, ula-1, zgc:66148Protein level used designations for NAE1
- APP-BP1-PA
- APP-BP1-PB
- CG7828-PA
- CG7828-PB
- APP-BP1
- NEDD8-activating enzyme E1 regulatory subunit
- NEDD8-activating enzyme E1 subunit
- amyloid beta precursor protein binding protein 1, 59kDa
- amyloid beta precursor protein-binding protein 1, 59 kDa
- amyloid beta precursor protein-binding protein 1, 59kD
- amyloid protein-binding protein 1
- proto-oncogene protein 1
- protooncogene protein 1
- APP-binding protein 1
- amyloid beta precursor protein binding protein 1
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