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MRVI1 蛋白

(Murine Retrovirus Integration Site 1 Homolog (MRVI1))

This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011].

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MRVI1 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2726428)

MRVI1 宿主: 人宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD

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Popular MRVI1 蛋白

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

MRVI1 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2726428

Quantity 20 μg

Datasheet Datasheet

Aliases for MRVI1 蛋白

MRV integration site 1 (Mrvi1) 蛋白
murine retrovirus integration site 1 homolog (MRVI1) 蛋白
BB115629 蛋白
Irag 蛋白
IRAG 蛋白
JAW1L 蛋白
Ris1 蛋白

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