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MPL 蛋白

(Myeloproliferative Leukemia Virus Oncogene (MPL))
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008].
MPL Protein (AA 26-491) (His tag) MPL Protein (AA 26-491) (His tag) MPL Protein (AA 26-491) (His tag) (ABIN7275276)

MPL 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

MPL Protein (AA 26-482) (His tag) MPL Protein (AA 26-482) (His tag) MPL Protein (AA 26-482) (His tag) (ABIN7275277)

MPL 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

MPL Protein (AA 1-635) (GST tag) MPL Protein (AA 1-635) (GST tag) MPL Protein (AA 1-635) (GST tag) (ABIN1311206)

MPL 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

MPL 蛋白 by Origin

Find MPL 蛋白 for a variety of species such as anti-Human MPL, anti-Mouse MPL, anti-Cynomolgus MPL. The species listed below are among those available. Click on a link to go to the corresponding products.

MPL 蛋白 by Source

Here you will find MPL 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

MPL 蛋白 by 蛋白类型

Here you can find MPL 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

MPL 蛋白 by 应用范围

Find MPL 蛋白 validated for a specific application such as SDS, WB, ELISA, AP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular MPL 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275276
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275277
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1311206
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124044
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7490615
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Baculovirus infected Insect Cells
Validations
  • (1)
Cat. No. ABIN7321113
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
Cat. No. ABIN7454193
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7406491
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7406458
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
Cat. No. ABIN1330315
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5709953
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Yeast
Validations
  • (1)
Cat. No. ABIN5713662
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3010794
Quantity 100 μg
Datasheet Datasheet

Aliases for MPL 蛋白

MPL proto-oncogene, thrombopoietin receptor (MPL) 蛋白
myeloproliferative leukemia virus oncogene (Mpl) 蛋白
MPL proto-oncogene, thrombopoietin receptor (Mpl) 蛋白
MPL proto-oncogene, thrombopoietin receptor (mpl) 蛋白
C-MPL 蛋白
c-mpl 蛋白
c-mpl-I 蛋白
c-mpl-II 蛋白
CD110 蛋白
hlb219 蛋白
MPL 蛋白
mpll 蛋白
MPLV 蛋白
THCYT2 蛋白
TPO-R 蛋白
TPOR 蛋白
tpor 蛋白
tpor.b 蛋白
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