MLL/KMT2A 产品
(Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))
Categories
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010].
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Featured MLL/KMT2A Categories
MLL/KMT2A 抗体
High quality antibodies with extensive validation data.
MLL/KMT2A 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MLL/KMT2A 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
IHC, ELISA
Validations
- (4)
Cat. No.
ABIN7189494
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (3)
- (2)
Cat. No.
ABIN969286
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, FACS, ICC, Neut
Validations
- (3)
Cat. No.
ABIN7193384
Quantity
100 μL
Datasheet
Datasheet
Recommended MLL/KMT2A 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN6579161
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our MLL/KMT2A Products
: "The IRX1/HOXA connection: insights into a novel t(4;11)- specific cancer mechanism." in: Oncotarget, Vol. 7, Issue 23, pp. 35341-52, (2016) (PubMed).: "Interaction of DNA demethylase and histone methyltransferase upregulates Nrf2 in 5-fluorouracil-resistant colon cancer cells." in: Oncotarget, Vol. 7, Issue 26, pp. 40594-40620, (2016) (PubMed).
: "Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer." in: Biochimica et biophysica acta, Vol. 1849, Issue 6, pp. 697-708, (2015) (PubMed).
: "Targeting the MLL complex in castration-resistant prostate cancer. ..." in: Nature medicine, Vol. 21, Issue 4, pp. 344-52, (2015) (PubMed).
: "NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1." in: Nature structural & molecular biology, Vol. 22, Issue 4, pp. 312-8, (2015) (PubMed).
: "Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL." in: Oncogenesis, Vol. 3, pp. e127, (2014) (PubMed).
: "Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins." in: Nucleic acids research, Vol. 42, Issue 14, pp. 9021-32, (2014) (PubMed).
: "RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction." in: Cell reports, Vol. 3, Issue 1, pp. 116-27, (2013) (PubMed).
: "c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis." in: The Journal of clinical investigation, Vol. 120, Issue 2, pp. 593-606, (2010) (PubMed).
: "Acute differentiated dendritic cell leukemia: a variant form of pediatric acute myeloid leukemia with MLL translocation." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 21, Issue 2, pp. 360-2, (2007) (PubMed).
Synonyms and alternative names related to MLL/KMT2A
lysine methyltransferase 2A (KMT2A), lysine (K)-specific methyltransferase 2A (Kmt2a), lysine methyltransferase 2A (Kmt2a), 6430520K01, ALL-1, All1, CXXC7, Cxxc7, HRX, HTRX1, mKIAA4050, MLL, Mll, MLL/GAS7, Mll1, MLL1A, TET1-MLL, TRX1, WDSTSProtein level used designations for MLL/KMT2A
- CDK6/MLL fusion protein
- CXXC-type zinc finger protein 7
- MLL-AF4 der(11) fusion protein
- MLL/GAS7 fusion protein
- MLL/GMPS fusion protein
- histone-lysine N-methyltransferase 2A
- lysine N-methyltransferase 2A
- myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
- myeloid/lymphoid or mixed-lineage leukemia protein 1
- trithorax-like protein
- zinc finger protein HRX
- histone-lysine N-methyltransferase MLL
- myeloid/lymphoid or mixed-lineage leukemia 1
- trithorax Drosophila
- Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene)
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