MKNK2 抗体
(MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011].
recommended
recommended
recommended
MKNK2 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, 斑马鱼, Bat, 猴, Pig WB, IHC (p), IHC 宿主: 兔 Polyclonal unconjugated
MKNK2 抗体 by 适用
Find MKNK2 抗体 for a variety of species such as anti-Mouse MKNK2, anti-Human MKNK2, anti-Rat MKNK2. The species listed below are among those available. Click on a link to go to the corresponding products.
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Find MKNK2 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.
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Find available monoclonal or polyclonal MKNK2 抗体. Click on a link to go to the corresponding products.
MKNK2 抗体 by 克隆
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Popular MKNK2 抗体
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Reactivity
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Validations
Cat. No.
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Datasheet
Reactivity
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Application
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Cat. No.
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Quantity
100 μg
Datasheet
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Application
WB, ELISA, IF
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Cat. No.
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Quantity
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Datasheet
Application
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Cat. No.
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Quantity
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Datasheet
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Cat. No.
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Quantity
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Application
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Cat. No.
ABIN634405
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
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Cat. No.
ABIN5675314
Quantity
100 μL
Datasheet
Datasheet
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Application
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Cat. No.
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Quantity
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Datasheet
Datasheet
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Application
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
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Cat. No.
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Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
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Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
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Validations
- (2)
Cat. No.
ABIN391228
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN5675315
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN6981962
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN6978427
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN6980081
Quantity
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Datasheet
Datasheet
Latest Publications for our MKNK2 抗体
: "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization." in: Molecular and cellular biology, Vol. 23, Issue 16, pp. 5692-705, (2003) (PubMed).: "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells." in: Molecular and cellular biology, Vol. 21, Issue 3, pp. 743-54, (2001) (PubMed).
: "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2." in: Molecular and cellular biology, Vol. 21, Issue 16, pp. 5500-11, (2001) (PubMed).
Aliases for MKNK2 抗体
MAP kinase interacting serine/threonine kinase 2 (MKNK2) 抗体MAP kinase interacting serine/threonine kinase 2 (mknk2) 抗体
MAP kinase-interacting serine/threonine kinase 2 (Mknk2) 抗体
MAP kinase interacting serine/threonine kinase 2b (mknk2b) 抗体
MAP kinase interacting serine/threonine kinase 2 L homeolog (mknk2.L) 抗体
MAP kinase interacting serine/threonine kinase 2 (Mknk2) 抗体
MAP kinase interacting serine/threonine kinase 2a (mknk2a) 抗体
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