MKNK2 产品
(MAP Kinase Interacting serine/threonine Kinase 2 (MKNK2))
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This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011].
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Featured MKNK2 Categories
Recommended MKNK2 抗体
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Reactivity
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Recommended MKNK2 ELISA试剂盒
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Recommended MKNK2 蛋白
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Reactivity
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Latest Publications for our MKNK2 Products
: "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization." in: Molecular and cellular biology, Vol. 23, Issue 16, pp. 5692-705, (2003) (PubMed).: "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells." in: Molecular and cellular biology, Vol. 21, Issue 3, pp. 743-54, (2001) (PubMed).
: "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2." in: Molecular and cellular biology, Vol. 21, Issue 16, pp. 5500-11, (2001) (PubMed).
Synonyms and alternative names related to MKNK2
MAP kinase interacting serine/threonine kinase 2 (MKNK2), MAP kinase interacting serine/threonine kinase 2 (mknk2), MAP kinase-interacting serine/threonine kinase 2 (Mknk2), MAP kinase interacting serine/threonine kinase 2b (mknk2b), MAP kinase interacting serine/threonine kinase 2 L homeolog (mknk2.L), MAP kinase interacting serine/threonine kinase 2 (Mknk2), MAP kinase interacting serine/threonine kinase 2a (mknk2a), 2010016G11Rik, fi34c11, GPRK7, gprk7, Gprk7, mknk2, MNK2, mnk2, Mnk2, wu:fb37e05, wu:fi34c11, wu:fi41e12, wz5090, zgc:55587Protein level used designations for MKNK2
- G protein-coupled receptor kinase 7
- MAP kinase signal-integrating kinase 2
- MAP kinase-interacting serine/threonine-protein kinase 2
- MAPK signal-integrating kinase 2
- MAP kinase interacting serine/threonine kinase 2
- MAP kinase-interacting serine/threonine kinase 2
- mnk2
- MAP kinase interacting serine/threonine kinase 2a
您还需要查找其他产品吗？
- MKNK1
- MKLN1
- MKL2
- MKL1
- MKL
- MKKS
- MK13
- MK03
- MIXL1
- Mitogen-Activated Protein Kinase Kinase Kinase 3
- Mitogen-Activated Protein Kinase Kinase Kinase 13
- Mitogen-Activated Protein Kinase Kinase 4
- Mitogen-Activated Protein Kinase Kinase 2
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase
- Mitochondrially Encoded NADH Dehydrogenase 4
- Mitochondrially Encoded ATP Synthase 8
- Mitochondrial Translation Elongation Factor EF-Ts Tsf1
- Mitochondrial Import Receptor Subunit TOM20 homolog
- Mitochondrial E3 Ubiquitin Protein Ligase 1
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