Minichromosome Maintenance Deficient 4 产品
(Minichromosome Maintenance Deficient 4 (MCM4))
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The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
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Featured Minichromosome Maintenance Deficient 4 Categories
Minichromosome Maintenance Deficient 4 抗体
High quality antibodies with extensive validation data.
Minichromosome Maintenance Deficient 4 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Minichromosome Maintenance Deficient 4 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Minichromosome Maintenance Deficient 4 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IP
Validations
- (7)
Cat. No.
ABIN950014
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), IF
Validations
- (6)
Cat. No.
ABIN517777
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, IF
Validations
- (3)
Cat. No.
ABIN7150334
Quantity
100 μg
Datasheet
Datasheet
Recommended Minichromosome Maintenance Deficient 4 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380406
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended Minichromosome Maintenance Deficient 4 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1310553
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1310555
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2725632
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our Minichromosome Maintenance Deficient 4 Products
: "Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells." in: Nature, Vol. 512, Issue 7513, pp. 198-202, (2014) (PubMed).: "Cohesin acetylation promotes sister chromatid cohesion only in association with the replication machinery." in: The Journal of biological chemistry, Vol. 287, Issue 41, pp. 34325-36, (2012) (PubMed).
: "The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia." in: Journal of immunological methods, Vol. 370, Issue 1-2, pp. 1-13, (2011) (PubMed).
: "Reducing MCM levels in human primary T cells during the G(0)-->G(1) transition causes genomic instability during the first cell cycle." in: Oncogene, Vol. 29, Issue 26, pp. 3803-14, (2010) (PubMed).
: "Expression, nuclear localization and interactions of human MCM/P1 proteins." in: Biochemical and biophysical research communications, Vol. 236, Issue 1, pp. 118-25, (1997) (PubMed).
: "A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins." in: European journal of biochemistry / FEBS, Vol. 230, Issue 3, pp. 1096-101, (1995) (PubMed).
: "The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins." in: Nucleic acids research, Vol. 21, Issue 23, pp. 5289-93, (1994) (PubMed).
: "Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication." in: Nucleic acids research, Vol. 20, Issue 21, pp. 5571-7, (1993) (PubMed).
: "A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication." in: Nucleic acids research, Vol. 21, Issue 11, pp. 2541-7, (1993) (PubMed).
Synonyms and alternative names related to Minichromosome Maintenance Deficient 4
minichromosome maintenance complex component 4 L homeolog (mcm4.L), minichromosome maintenance complex component 4 S homeolog (mcm4.S), minichromosome maintenance complex component 4 (MCM4), minichromosome maintenance complex component 4 (mcm4), minichromosome maintenance complex component 4 (Mcm4), 19G, AI325074, AU045576, cb1025, cdc21, CDC21, Cdc21, CDC54, fc12c09, fj85g09, hCdc21, hm:zeh1616, mcdc21, Mcmd4, mKIAA4003, NKCD, NKGCD, P1-CDC21, wu:fc12c09, wu:fj85g09, zeh1616Protein level used designations for Minichromosome Maintenance Deficient 4
- DNA replication licensing factor mcm4-B
- xMCM4-B
- P1-CDC21-B
- CDC21 homolog-B
- minichromosome maintenance protein 4-B
- CDC21 homolog-A
- DNA replication licensing factor mcm4-A
- P1-CDC21-A
- minichromosome maintenance deficient 4
- minichromosome maintenance protein 4-A
- p98
- xMCM4-A
- CDC21 homolog
- DNA replication licensing factor MCM4
- homolog of S. pombe cell devision cycle 21
- MCM4 minichromosome maintenance deficient 4
- DNA replication licensing factor mcm4
- minichromosome maintenance protein 4
- P1-CDC21
- mini chromosome maintenance deficient 4 homolog
- minichromosome maintenance deficient 4 homolog
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