MEG3 产品
(Family with Sequence Similarity 129, Member B (FAM129B))
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MEG3 (Maternally Expressed Gene 3) is a long non-coding RNA (lncRNA) that is part of the DLK1-MEG3 locus on chromosome 14q32.3. This locus is imprinted, meaning that genes from only one parental allele are expressed while the other allele is silenced. Specifically, MEG3 is maternally expressed and paternally silenced.
- Tumor Suppressor: MEG3 has been identified as a tumor suppressor in various types of cancers. Its expression is often downregulated in tumor tissues compared to normal tissues. The loss of MEG3 expression has been associated with tumor progression and poor prognosis in several cancers.
- Regulation of Cell Proliferation and Apoptosis: MEG3 plays a role in controlling cell proliferation and promoting apoptosis. Its downregulation can lead to increased cell proliferation and reduced apoptosis, which can contribute to tumorigenesis.
- Modulation of p53 Pathway: MEG3 can enhance the activity of the p53 protein, a critical tumor suppressor. By modulating the p53 pathway, MEG3 can influence cell cycle arrest, apoptosis, and DNA repair.
- Role in Neural Development: Apart from its role in cancer, MEG3 is also involved in neural development. It is expressed in the brain and has been implicated in the differentiation of neural stem cells.
- Interaction with Other Molecules: As an lncRNA, MEG3 can interact with various molecules in the cell, including proteins, other RNAs, and DNA. These interactions can influence gene expression, protein activity, and cellular functions.
- Epigenetic Regulation: MEG3 is involved in the epigenetic regulation of genes. It can recruit chromatin-modifying enzymes to specific genomic regions, leading to changes in gene expression.
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Featured MEG3 Categories
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Latest Publications for our MEG3 Products
: "Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163." in: Tumour biology, Vol. 37, Issue 3, pp. 3925-31, (2016) (PubMed).: "Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway." in: American journal of translational research, Vol. 8, Issue 2, pp. 1091-9, (2016) (PubMed).
: "FAM129B is a novel regulator of Wnt/β-catenin signal transduction in melanoma cells." in: F1000Research, Vol. 2, pp. 134, (2014) (PubMed).
Synonyms and alternative names related to MEG3
family with sequence similarity 129 member B (FAM129B), family with sequence similarity 129 member B S homeolog (fam129b.S), family with sequence similarity 129 member B (fam129b), family with sequence similarity 129, member B (Fam129b), family with sequence similarity 129, member Ba (fam129ba), 9130404D14Rik, bA356B19.6, C9orf88, fam129b, MEG-3, MGC82535, MINERVA, OC58, RGD1307018, zgc:158319Protein level used designations for MEG3
- melanoma invasion by ERK
- niban-like protein 1
- family with sequence similarity 129, member B
- hypothetical protein LOC100145245
- Niban-like protein 1
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