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MED17 产品

(Mediator Complex Subunit 17 (MED17))
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008].

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Featured MED17 Categories

MED17 抗体

High quality antibodies with extensive validation data.

MED17 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

MED17 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MED17 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p)
Validations
  • (2)
  • (5)
Cat. No. ABIN564067
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse, Rat
Application IHC, IF
Validations
  • (4)
Cat. No. ABIN7074579
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application WB, IHC, ChIP
Validations
  • (4)
Cat. No. ABIN2778320
Quantity 100 μL
Datasheet Datasheet

Recommended MED17 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN1743276
Quantity 96 tests
Datasheet Datasheet
Reactivity Sheep
Analytical Method
Validations
Cat. No. ABIN1774181
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN1744495
Quantity 96 tests
Datasheet Datasheet

Recommended MED17 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310642
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310641
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3093816
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our MED17 Products

Kikuchi, Umemura, Nishitani, Iida, Fukasawa, Hayashi, Hirose, Tanaka, Sugasawa, Ohkuma: "Human mediator MED17 subunit plays essential roles in gene regulation by associating with the transcription and DNA repair machineries." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 20, Issue 3, pp. 191-202, (2015) (PubMed).

Tsutsui, Fukasawa, Shinmyouzu, Nakagawa, Tobe, Tanaka, Ohkuma: "Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes." in: The Journal of biological chemistry, Vol. 288, Issue 29, pp. 20955-65, (2013) (PubMed).

Tsutsui, Fukasawa, Tanaka, Hirose, Ohkuma: "Identification of target genes for the CDK subunits of the Mediator complex." in: Genes to cells : devoted to molecular & cellular mechanisms, (2011) (PubMed).

Synonyms and alternative names related to MED17

mediator of RNA polymerase II transcription subunit 17 (AOR_1_2446154), mediator of RNA polymerase II transcription subunit 17 (VDBG_01663), mediator complex subunit 17 (med17), mediator complex subunit 17 L homeolog (med17.L), mediator complex subunit 17 (MED17), mediator complex subunit 17 (Med17), 77kDa, C330002H14Rik, crsp6, CRSP6, Crsp6, CRSP77, DRIP80, TRAP80, Trap80

Protein level used designations for MED17

  • mediator of RNA polymerase II transcription subunit 17
  • Mediator of RNA polymerase II transcription subunit 17
  • CRSP complex subunit 6
  • cofactor required for Sp1 transcriptional activation subunit 6
  • cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa
  • ARC77
  • activator-recruited cofactor 77 kDa component
  • thyroid hormone receptor-associated protein complex 80 kDa component
  • transcriptional coactivator CRSP77
  • vitamin D3 receptor-interacting protein complex 80 kDa component
  • cofactor required for Sp1 transcriptional activation, subunit 6 (77kD)
  • cofactor required for Sp1 transcriptional activation, subunit 6
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