This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008].
Find MC1 Receptor 抗体 for a variety of species such as anti-Human MC1 Receptor, anti-Mouse MC1 Receptor, anti-E. coli MC1 Receptor. The species listed below are among those available. Click on a link to go to the corresponding products.
MC1 Receptor 抗体 by 应用范围
Find MC1 Receptor 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.
MC1 Receptor 抗体 by 抗体来源
Find MC1 Receptor 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.
MC1 Receptor 抗体 by 抗原表位
Find MC1 Receptor 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.
MC1 Receptor 抗体 by 克隆形成能力
Find available monoclonal or polyclonal MC1 Receptor 抗体. Click on a link to go to the corresponding products.
MC1 Receptor 抗体 by 克隆
Find MC1 Receptor 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.
MC1 Receptor 抗体 by 标记
Find MC1 Receptor 抗体 with a specific conjugate such as FITC, Biotin, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
Bekeschus, Rödder, Fregin, Otto, Lippert, Weltmann, Wende, Schmidt, Gandhirajan: "Toxicity and Immunogenicity in Murine Melanoma following Exposure to Physical Plasma-Derived Oxidants." in: Oxidative medicine and cellular longevity, Vol. 2017, pp. 4396467, (2018) (PubMed).
Schmitz, Botte, Sotto, Borba, Bonfa, de Mello: "Increased corticotropin-releasing hormone (CRH) expression in cutaneous lupus lesions." in: Lupus, Vol. 24, Issue 8, pp. 854-61, (2015) (PubMed).