MBD2 产品
(Methyl-CpG Binding Domain Protein 2 (MBD2))
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DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
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Latest Publications for our MBD2 Products
: "lncRNA PAPAS tethered to the rDNA enhancer recruits hypophosphorylated CHD4/NuRD to repress rRNA synthesis at elevated temperatures." in: Genes & development, Vol. 32, Issue 11-12, pp. 836-848, (2018) (PubMed).: "Specificity in circadian clock feedback from targeted reconstitution of the NuRD corepressor." in: Molecular cell, Vol. 56, Issue 6, pp. 738-48, (2014) (PubMed).
: "A SILAC-based screen for Methyl-CpG binding proteins identifies RBP-J as a DNA methylation and sequence-specific binding protein." in: PLoS ONE, Vol. 6, Issue 10, pp. e25884, (2012) (PubMed).
: "CDK2AP1/DOC-1 is a bona fide subunit of the Mi-2/NuRD complex." in: Molecular bioSystems, Vol. 6, Issue 9, pp. 1700-6, (2010) (PubMed).
: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).
: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, (2010) (PubMed).
: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, (2009) (PubMed).
: "Epigenetic silence of ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive ..." in: Hepatology (Baltimore, Md.), Vol. 51, Issue 1, pp. 142-53, (2009) (PubMed).
: "Control of the DNA methylation system component MBD2 by protein arginine methylation." in: Molecular and cellular biology, Vol. 26, Issue 19, pp. 7224-35, (2006) (PubMed).
: "MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties." in: Molecular and cellular biology, Vol. 26, Issue 3, pp. 843-51, (2006) (PubMed).
Synonyms and alternative names related to MBD2
methyl-CpG binding domain protein 2 (MBD2), methyl-CpG binding domain protein 2 (Mbd2), methyl-CpG binding domain protein 2 (mbd2), methyl-CpG binding domain protein 2 S homeolog (mbd2.S), DMTase, MBD2, MBD2a, NY-CO-41, wu:fa97f06, zgc:111862Protein level used designations for MBD2
- methyl-CpG binding domain protein 2
- demethylase
- methyl-CpG-binding domain protein 2
- methyl-CpG-binding protein MBD2
- methyl-CpG binding protein MBD2
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