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MAX 产品

(MYC Associated Factor X (MAX))

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The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].

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Featured MAX Categories

MAX 抗体

High quality antibodies with extensive validation data.

MAX ELISA试剂盒

Reliable ELISA kits for a wide range of species.

MAX 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MAX 抗体

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Reactivity
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Datasheet
Reactivity Human
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Cat. No. ABIN561745
Quantity 100 μg
Datasheet Datasheet
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Cat. No. ABIN184586
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Cat. No. ABIN7165797
Quantity 100 μg
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Recommended MAX ELISA试剂盒

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Reactivity
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Cat. No.
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Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
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Cat. No. ABIN6968708
Quantity 96 tests
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Reactivity Human
Analytical Method Quantitative Sandwich ELISA
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Cat. No. ABIN6957925
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Reactivity Mouse
Analytical Method
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Cat. No. ABIN1151943
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Recommended MAX 蛋白

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Reactivity
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Validations
Cat. No.
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Datasheet
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Cat. No. ABIN666983
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Reactivity Human
Source Wheat germ
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Cat. No. ABIN1310452
Quantity 10 μg
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Reactivity Human
Source Escherichia coli (E. coli)
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Cat. No. ABIN7319268
Quantity 50 μg
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Latest Publications for our MAX Products

Wang, Yang, Zhang, Guo, Wu, Wang, Jia, Li, Xie, Yang: "lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer." in: Cancer cell, Vol. 33, Issue 4, pp. 706-720.e9, (2019) (PubMed).

Pichulik, Khatamzas, Liu, Brain, Delmiro Garcia, Leslie, Danis, Mayer, Baban, Ragoussis, Weber, Simmons: "Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with influenza A virus." in: European journal of immunology, Vol. 46, Issue 1, pp. 167-77, (2016) (PubMed).

Ikeda, Pak, Chavez, Ryan: "Transcription factors with conserved binding sites near ATOH1 on the POU4F3 gene enhance the induction of cochlear hair cells." in: Molecular neurobiology, Vol. 51, Issue 2, pp. 672-84, (2015) (PubMed).

Qin, de Cubas, Garcia-Martin, Richter, Peitzsch, Menschikowski, Lenders, Timmers, Mannelli, Opocher, Economopoulou, Siegert, Chavakis, Pacak, Robledo, Eisenhofer: "Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X." in: International journal of cancer, Vol. 135, Issue 9, pp. 2054-64, (2014) (PubMed).

Faiola, Wu, Pan, Zhang, Farina, Martinez: "Max is acetylated by p300 at several nuclear localization residues." in: The Biochemical journal, Vol. 403, Issue 3, pp. 397-407, (2007) (PubMed).

Gordan, Bertout, Hu, Diehl, Simon: "HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity." in: Cancer cell, Vol. 11, Issue 4, pp. 335-47, (2007) (PubMed).

Fujii, Lyakh, Bracken, Fukuoka, Hayakawa, Tsukiyama, Soll, Harris, Rocha, Roche, Tominaga, Jen, Perkins, Lechleider, Roberts: "SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes." in: Molecular cell, Vol. 24, Issue 5, pp. 771-83, (2006) (PubMed).

Magid, Murphy, Galis: "Expression of matrix metalloproteinase-9 in endothelial cells is differentially regulated by shear stress. Role of c-Myc." in: The Journal of biological chemistry, Vol. 278, Issue 35, pp. 32994-9, (2003) (PubMed).

Blackwood, Eisenman: "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc." in: Science (New York, N.Y.), Vol. 251, Issue 4998, pp. 1211-7, (1991) (PubMed).

Synonyms and alternative names related to MAX

CG9648 gene product from transcript CG9648-RD (Max), MYC associated factor X L homeolog (max.L), MYC associated factor X (MAX), MYC associated factor X (max), Max protein (Max), MYC associated factor X S homeolog (max.S), MYC associated factor X (Max), myc associated factor X (max), AA960152, AI875693, bhlhd4, bHLHd4, bhlhd5, bHLHd5, bhlhd6, bHLHd6, bhlhd7, bHLHd7, bhlhd8, bHLHd8, bHLHd9, CG9648, dMax, dmax, Dmel\\CG9648, fa92b04, fb52a04, fb95h11, MAX, max, wu:fa92b04, wu:fb52a04, wu:fb95h11, xmax, xmax2, xmax4, zmax

Protein level used designations for MAX

  • CG9648-PA
  • CG9648-PC
  • Max-PA
  • Max-PC
  • Max homologue 2
  • Myc binding protein Xmax4
  • myc-associated factor X
  • protein max
  • xMAX
  • MYC associated factor X
  • myc-binding novel HLH/LZ protein
  • protein myn
  • class D basic helix-loop-helix protein 4
  • Myc binding protein Xmax2
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