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MARCH8 产品

(Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))

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MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]\; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010].

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Featured MARCH8 Categories

MARCH8 抗体

High quality antibodies with extensive validation data.

MARCH8 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MARCH8 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN566949
Quantity 50 μL
Datasheet Datasheet

Application WB
Validations
  • (1)
Cat. No. ABIN6743175
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Guinea Pig, Human
Application WB
Validations
  • (1)
Cat. No. ABIN6743135
Quantity 100 μL
Datasheet Datasheet

Recommended MARCH8 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310377
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1310379
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2725820
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our MARCH8 Products

Tada, Zhang, Koyama, Tobiume, Tsunetsugu-Yokota, Yamaoka, Fujita, Tokunaga: "MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins." in: Nature medicine, Vol. 21, Issue 12, pp. 1502-7, (2015) (PubMed).

Bartee, Mansouri, Hovey Nerenberg, Gouveia, Früh: "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins." in: Journal of virology, Vol. 78, Issue 3, pp. 1109-20, (2004) (PubMed).

Goto, Ishido, Sato, Ohgimoto, Ohgimoto, Nagano-Fujii, Hotta: "c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity." in: The Journal of biological chemistry, Vol. 278, Issue 17, pp. 14657-68, (2003) (PubMed).

Synonyms and alternative names related to MARCH8

membrane associated ring-CH-type finger 8 (MARCH8), membrane-associated ring finger (C3HC4) 8 (march8), membrane-associated ring finger (C3HC4) 8 (March8), membrane associated ring-CH-type finger 8 (March8), membrane associated ring-CH-type finger 8 (march8), membrane associated ring-CH-type finger 8 L homeolog (march8.L), 1300017E09Rik, c-MIR, Mar-08, MARCH-VIII, MARCH8, MIR, Mir, RNF178, zgc:171495

Protein level used designations for MARCH8

  • E3 ubiquitin-protein ligase MARCH8
  • RING finger protein 178
  • c-mir, cellular modulator of immune recognition
  • cellular modulator of immune recognition (c-MIR)
  • membrane-associated RING finger protein 8
  • membrane-associated RING-CH protein VIII
  • MARCH-VIII
  • cellular modulator of immune recognition
  • membrane-associated ring finger (C3HC4) 8
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