MAPK8IP1 产品
(Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))
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This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011].
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Featured MAPK8IP1 Categories
MAPK8IP1 抗体
High quality antibodies with extensive validation data.
MAPK8IP1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended MAPK8IP1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
Cat. No.
ABIN2854806
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p), FACS
Validations
- (4)
Cat. No.
ABIN652961
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, IHC
Validations
- (2)
Cat. No.
ABIN3185263
Quantity
100 μL
Datasheet
Datasheet
Recommended MAPK8IP1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6227128
Quantity
96 tests
Datasheet
Datasheet
Recommended MAPK8IP1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3093174
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3137545
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2725443
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our MAPK8IP1 Products
: "Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons." in: The Journal of biological chemistry, Vol. 274, Issue 49, pp. 35113-8, (2000) (PubMed).: "IB1, a JIP-1-related nuclear protein present in insulin-secreting cells." in: The Journal of biological chemistry, Vol. 273, Issue 4, pp. 1843-6, (1998) (PubMed).
: "A cytoplasmic inhibitor of the JNK signal transduction pathway." in: Science (New York, N.Y.), Vol. 277, Issue 5326, pp. 693-6, (1997) (PubMed).
Synonyms and alternative names related to MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1), mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1), IB1, JIP-1, Jip-1, Jip1, JIP1, Mapk8ip, mjip-2a, Prkm8ip, PRKM8IP, SkipProtein level used designations for MAPK8IP1
- mitogen-activated protein kinase 8 interacting protein 1
- c-Jun-amino-terminal kinase-interacting protein 1-like
- C-Jun-amino-terminal kinase-interacting protein 1
- IB-1
- JNK MAP kinase scaffold protein 1
- JNK-interacting protein 1
- islet-brain-1
- mitogen activated protein kinase 8 interacting protein 1
- mitogen-activated protein kinase 8-interacting protein 1
- protein kinase, mitogen-activated 8 interacting protein
- JIP-1-related protein
- JRP
- mitogen activated protein kinase 8 interacting protein
- PRKM8 interacting protein
- islet-brain 1
- islet brain 1
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