MAPK10 产品
(Mitogen-Activated Protein Kinase 10 (MAPK10))
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The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Featured MAPK10 Categories
Recommended MAPK10 抗体
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Reactivity
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Datasheet
Reactivity
Human
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ABIN3022948
Quantity
100 μL
Datasheet
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Cat. No.
ABIN5542487
Quantity
100 μL
Datasheet
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Reactivity
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Application
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Cat. No.
ABIN7429106
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Recommended MAPK10 ELISA试剂盒
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ABIN6213165
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Recommended MAPK10 蛋白
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ABIN1783176
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Reactivity
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Insect Cells
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ABIN5508978
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Latest Publications for our MAPK10 Products
: "EphrinB2 controls vessel pruning through STAT1-JNK3 signalling." in: Nature communications, Vol. 6, pp. 6576, (2015) (PubMed).: "JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis." in: PLoS ONE, Vol. 9, Issue 1, pp. e87067, (2014) (PubMed).
: "Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin." in: Molecular biology of the cell, Vol. 19, Issue 10, pp. 4201-12, (2008) (PubMed).
: "The lectin jacalin induces phosphorylation of ERK and JNK in CD4+ T cells." in: Journal of leukocyte biology, Vol. 73, Issue 5, pp. 682-8, (2003) (PubMed).
: "Role of mitogen- and stress-activated kinases in ischemic injury." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 22, Issue 6, pp. 631-47, (2002) (PubMed).
: "Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene." in: Journal of human genetics, Vol. 47, Issue 11, pp. 614-9, (2002) (PubMed).
: "Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3." in: The EMBO journal, Vol. 21, Issue 3, pp. 324-33, (2002) (PubMed).
: "gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes." in: Blood, Vol. 100, Issue 7, pp. 2546-53, (2002) (PubMed).
: "Mitogen-activated protein kinase kinase 4 (MKK4)." in: The international journal of biochemistry & cell biology, Vol. 32, Issue 6, pp. 581-7, (2000) (PubMed).
: "Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3." in: Science (New York, N.Y.), Vol. 290, Issue 5496, pp. 1574-7, (2000) (PubMed).
Synonyms and alternative names related to MAPK10
mitogen-activated protein kinase 8 S homeolog (mapk8.S), mitogen-activated protein kinase 10 (MAPK10), mitogen-activated protein kinase 10 (mapk10), mitogen activated protein kinase 10 (Mapk10), mitogen-activated protein kinase 10 (Mapk10), MAP kinase 10 (MPK10), ATMPK10, C230008H04Rik, DKFZp459H0638, Jnk3, JNK3, JNK3A, JNK3B1, JNK3B2, MAPK10, MAP kinase 10, p54bSAPK, p493F12, PRKM10, SAPb, SAPK(beta), SAPK1b, SAPKC, Serk2, zgc:123234Protein level used designations for MAPK10
- mitogen-activated protein kinase 10
- jnk3
- MAP kinase 10
- MAPK 10
- SAPK-beta
- Stress activated protein kinase beta
- c-Jun N-terminal kinase 3
- p54-beta
- stress-activated protein kinase JNK3
- JNK3 alpha protein kinase
- MAP kinase p49 3F12
- stress activated protein kinase beta
- stress-activated protein kinase 1b
- JNK3 beta1 protein kinase
- JNK3 beta2 protein kinase
- SAPK/Erk/kinase 2
- mitogen activated protein kinase 10
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