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MAP3K8 抗体

(Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011].

recommended

MAP3K8 抗体 (AA 121-220) (ABIN701275)

MAP3K8 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

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recommended

MAP3K8 抗体 (AA 1-300) (ABIN7160057)

MAP3K8 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

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recommended

MAP3K8 抗体 (pThr290) (ABIN6255657)

MAP3K8 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

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MAP3K8 抗体 by 适用

Find MAP3K8 抗体 for a variety of species such as anti-Human MAP3K8, anti-Rat MAP3K8, anti-Mouse MAP3K8. The species listed below are among those available. Click on a link to go to the corresponding products.

MAP3K8 抗体 by 应用范围

Find MAP3K8 抗体 validated for a specific application such as WB, ELISA, IHC, IHC (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

MAP3K8 抗体 by 抗体来源

Find MAP3K8 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.

MAP3K8 抗体 by 抗原表位

Find MAP3K8 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

MAP3K8 抗体 by 克隆形成能力

Find available monoclonal or polyclonal MAP3K8 抗体. Click on a link to go to the corresponding products.

MAP3K8 抗体 by 克隆

Find MAP3K8 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

MAP3K8 抗体 by 标记

Find MAP3K8 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular MAP3K8 抗体

Product

Reactivity

Application

Validations

Cat. No.

Quantity

Datasheet

anti-MAP3K8 抗体 (AA 121-220)

Reactivity Human, Mouse, Rat

Application WB, ELISA, IHC (p)

Validations

Cat. No. ABIN701275

Quantity 100 μL

Datasheet Datasheet

anti-MAP3K8 抗体 (AA 1-300)

Reactivity Human

Application ELISA, IHC, IF

Validations

Cat. No. ABIN7160057

Quantity 100 μg

Datasheet Datasheet

anti-MAP3K8 抗体 (pThr290)

Reactivity Human, Mouse, Rat

Application WB, ELISA, IHC, IF, ICC

Validations

Cat. No. ABIN6255657

Quantity 100 μL

Datasheet Datasheet

anti-MAP3K8 抗体

Reactivity Human

Application WB, IHC (p), IF, ICC

Validations

Cat. No. ABIN2855464

Quantity 100 μL

Datasheet Datasheet

anti-MAP3K8 抗体 (AA 256-305)

Reactivity Human, Mouse, Rat

Application WB, ELISA, IHC, IHC (p), IF

Validations

Cat. No. ABIN2888594

Quantity 100 μL

Datasheet Datasheet

anti-MAP3K8 抗体 (Ser400)

Reactivity Human

Application WB, ELISA, IHC

Validations

Cat. No. ABIN7180044

Quantity 100 μL

Datasheet Datasheet

anti-MAP3K8 抗体 (C-Term)

Reactivity Human

Application WB, IHC (p)

Validations

Cat. No. ABIN392472

Quantity 400 μL

Datasheet Datasheet

anti-MAP3K8 抗体 (pSer290)

Reactivity Cow, Human, Monkey, Mouse, Rat

Application WB, IHC, IF, IC

Validations

Cat. No. ABIN7299172

Quantity 100 μL

Datasheet Datasheet

anti-MAP3K8 抗体 (pSer400)

Reactivity Human, Mouse, Rat

Application WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), FACS

Validations

Cat. No. ABIN746573

Quantity 100 μL

Datasheet Datasheet

anti-MAP3K8 抗体 (pThr290)

Reactivity Human, Rat

Application ELISA, IHC (p), IF (cc), IF (p), IHC (fro)

Validations

Cat. No. ABIN746588

Quantity 100 μL

Datasheet Datasheet

anti-MAP3K8 抗体 (pThr290)

Reactivity Human

Application WB, ELISA, IHC, IF

Validations

Cat. No. ABIN7180879

Quantity 100 μg

Datasheet Datasheet

anti-MAP3K8 抗体 (AA 35-84)

Reactivity Cow, Horse, Human, Mouse

Application WB

Validations

Cat. No. ABIN6742194

Quantity 100 μL

Datasheet Datasheet

anti-MAP3K8 抗体 (C-Term)

Reactivity Bat, Cow, Dog, Human, Monkey

Application IHC, IHC (p)

Validations

Cat. No. ABIN1049034

Quantity 50 μg

Datasheet Datasheet

anti-MAP3K8 抗体 (AA 396-445)

Reactivity Bat, Cow, Dog, Hamster, Horse, Human, Monkey, Rabbit, Rat

Application WB

Validations

Cat. No. ABIN202595

Quantity 100 μL

Datasheet Datasheet

anti-MAP3K8 抗体 (AA 1-100)

Reactivity Human

Application WB

Validations

Cat. No. ABIN7268661

Quantity 100 μL

Datasheet Datasheet

Latest Publications for our MAP3K8 抗体

Jeong, Bhatia, Toth, Oh, Inn, Liao, Roy-Burman, Melamed, Coetzee, Jung: "TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth." in: PLoS ONE, Vol. 6, Issue 1, pp. e16205, (2011) (PubMed).

Jager, Grémeaux, Gonzalez, Bonnafous, Debard, Laville, Vidal, Tran, Gual, Le Marchand-Brustel, Cormont, Tanti: "Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis." in: Diabetes, Vol. 59, Issue 1, pp. 61-70, (2009) (PubMed).

Mielke, Elkins, Wei, Starr, Tsichlis, OShea, Watford: "Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 12, pp. 7984-93, (2009) (PubMed).

ONeill: "When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction." in: Immunity, Vol. 29, Issue 1, pp. 12-20, (2008) (PubMed).

Sánchez-Góngora, Lisbona, de Gregorio, Ballester, Calvo, Pérez-Jurado, Alemany: "COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation." in: The Journal of biological chemistry, Vol. 275, Issue 40, pp. 31379-86, (2000) (PubMed).

Aliases for MAP3K8 抗体

mitogen-activated protein kinase kinase kinase 8 (MAP3K8) 抗体
mitogen-activated protein kinase kinase kinase 8 (map3k8) 抗体
mitogen-activated protein kinase kinase kinase 8 (Map3k8) 抗体
c-COT 抗体
COT 抗体
Cot 抗体
Cot/Tpl2 抗体
D17TPL2 抗体
EST 抗体
Est 抗体
ESTF 抗体
Estf 抗体
MAP3K8 抗体
MEKK8 抗体
Tpl-2 抗体
TPL2 抗体
Tpl2 抗体

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Popular MAP3K8 抗体

Latest Publications for our MAP3K8 抗体

Aliases for MAP3K8 抗体

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