MAP3K3 抗体
(Mitogen-Activated Protein Kinase Kinase Kinase 3 (MAP3K3))
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively\; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
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MAP3K3 抗体 by 抗原表位
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MAP3K3 抗体 by 克隆形成能力
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MAP3K3 抗体 by 标记
Find MAP3K3 抗体 with a specific conjugate such as Biotin, APC, FITC. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
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Reactivity
Application
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Quantity
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Cat. No.
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Quantity
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Datasheet
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Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, IHC, IF, IC
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Cat. No.
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Quantity
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Datasheet
Datasheet
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Application
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Cat. No.
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Quantity
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Datasheet
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Reactivity
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Quantity
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Datasheet
Datasheet
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Cat. No.
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Quantity
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Datasheet
Datasheet
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Cat. No.
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Quantity
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Datasheet
Datasheet
Reactivity
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Cat. No.
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Quantity
50 μg
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
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Cat. No.
ABIN517854
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
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Validations
Cat. No.
ABIN6944073
Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IHC, IF
Validations
- (1)
Cat. No.
ABIN6284877
Quantity
50 μL
Datasheet
Datasheet
Reactivity
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Application
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Validations
Cat. No.
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Quantity
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Datasheet
Datasheet
Latest Publications for our MAP3K3 抗体
: "Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways." in: Anticancer research, Vol. 30, Issue 6, pp. 2135-43, (2010) (PubMed).: "PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 36989-92, (2003) (PubMed).
: "Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3." in: Nature immunology, Vol. 5, Issue 1, pp. 98-103, (2003) (PubMed).
: "Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock." in: Nature cell biology, Vol. 5, Issue 12, pp. 1104-10, (2003) (PubMed).
: "Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein Kinase/ERK kinase kinase 3 ..." in: The Journal of biological chemistry, Vol. 272, Issue 5, pp. 2668-74, (1997) (PubMed).
Aliases for MAP3K3 抗体
mitogen activated protein kinase kinase kinase 3 (Map3k3) 抗体mitogen-activated protein kinase kinase kinase 3 (MAP3K3) 抗体
mitogen-activated protein kinase kinase kinase 3 (Map3k3) 抗体
mitogen-activated protein kinase kinase kinase 3 (map3k3) 抗体
AW548911 抗体
MAPKKK3 抗体
MEKK3 抗体
Mekk3 抗体
mKIAA4031 抗体
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