MANF 抗体
(Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of polymorphisms in the arginine-rich region, including a specific mutation that changes the previously numbered codon 50 from ATG to AGG, have been reported in a variety of solid tumors\; however, these polymorphisms were later shown to exist in normal tissues and are thus not tumor-related. [provided by RefSeq, Jun 2010].
recommended
recommended
recommended
KO Validated MANF 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
MANF 抗体 by Grade
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MANF 抗体 by 应用范围
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MANF 抗体 by 克隆形成能力
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MANF 抗体 by 克隆
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MANF 抗体 by 标记
Find MANF 抗体 with a specific conjugate such as Biotin, FITC, APC. The conjugates listed below are among those available. Click on a link to go to the corresponding products.
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Quantity
100 μL
Datasheet
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Latest Publications for our MANF 抗体
: "Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss." in: Cell death & disease, Vol. 11, Issue 2, pp. 100, (2020) (PubMed).: "Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice." in: Neurobiology of disease, Vol. 134, pp. 104696, (2020) (PubMed).
: "MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System." in: eNeuro, Vol. 7, Issue 1, (2020) (PubMed).
: "MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex." in: eNeuro, Vol. 4, Issue 5, (2018) (PubMed).
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
: "MANF regulates dopaminergic neuron development in larval zebrafish." in: Developmental biology, Vol. 370, Issue 2, pp. 237-49, (2012) (PubMed).
: "Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo." in: Nature, Vol. 448, Issue 7149, pp. 73-7, (2007) (PubMed).
: "MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons." in: Journal of molecular neuroscience : MN, Vol. 20, Issue 2, pp. 173-88, (2003) (PubMed).
: "Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck." in: Cancer research, Vol. 56, Issue 24, pp. 5576-8, (1997) (PubMed).
: "A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas." in: Oncogene, Vol. 12, Issue 9, pp. 1931-9, (1996) (PubMed).
Aliases for MANF 抗体
mesencephalic astrocyte derived neurotrophic factor (MANF) 抗体mesencephalic astrocyte-derived neurotrophic factor (Manf) 抗体
RNA binding motif protein 15B (RBM15B) 抗体
Mesencephalic astrocyte-derived neurotrophic factor (Manf) 抗体
mesencephalic astrocyte-derived neurotrophic factor (manf) 抗体
mesencephalic astrocyte derived neurotrophic factor (Manf) 抗体
mesencephalic astrocyte-derived neurotrophic factor S homeolog (manf.S) 抗体
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im:6909481 抗体
MANF 抗体
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