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Lysine (K)-Specific Methyltransferase 2A 抗体

(Lysine (K)-Specific Methyltransferase 2A (KMT2A))
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis (By similarity).
Lysine (K)-Specific Methyltransferase 2A (KMT2A) (AA 720-780), (N-Term) 抗体 Lysine (K)-Specific Methyltransferase 2A (KMT2A) (AA 720-780), (N-Term) 抗体 Lysine (K)-Specific Methyltransferase 2A (KMT2A) (AA 720-780), (N-Term) 抗体 (ABIN328575)

KMT2A 适用: 人, 小鼠 WB, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated

Lysine (K)-Specific Methyltransferase 2A (KMT2A) (AA 3879-3908) 抗体 (ABIN1840980)

KMT2A 适用: 人 IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated

Lysine (K)-Specific Methyltransferase 2A (KMT2A) (AA 2725-2775) 抗体 (ABIN1908616)

KMT2A 适用: 人, 小鼠, 马, 豚鼠, 大鼠 WB, IP, ChIP, PLA 宿主: 兔 Polyclonal unconjugated

Lysine (K)-Specific Methyltransferase 2A 抗体 by 适用

Find Lysine (K)-Specific Methyltransferase 2A 抗体 for a variety of species such as anti-Human Lysine (K)-Specific Methyltransferase 2A, anti-Mouse Lysine (K)-Specific Methyltransferase 2A, anti-Horse Lysine (K)-Specific Methyltransferase 2A. The species listed below are among those available. Click on a link to go to the corresponding products.

Lysine (K)-Specific Methyltransferase 2A 抗体 by 应用范围

Find Lysine (K)-Specific Methyltransferase 2A 抗体 validated for a specific application such as ELISA, WB, IHC, IP. Some of the available applications are listed below. Click on a link to go to the corresponding products.

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Find Lysine (K)-Specific Methyltransferase 2A 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.

Lysine (K)-Specific Methyltransferase 2A 抗体 by 抗原表位

Find Lysine (K)-Specific Methyltransferase 2A 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

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Find available monoclonal or polyclonal Lysine (K)-Specific Methyltransferase 2A 抗体. Click on a link to go to the corresponding products.

Lysine (K)-Specific Methyltransferase 2A 抗体 by 克隆

Find Lysine (K)-Specific Methyltransferase 2A 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

Lysine (K)-Specific Methyltransferase 2A 抗体 by 标记

Find Lysine (K)-Specific Methyltransferase 2A 抗体 with a specific conjugate such as APC, Biotin, FITC. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular Lysine (K)-Specific Methyltransferase 2A 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, IHC, IHC (p), FACS
Validations
  • (2)
Cat. No. ABIN328575
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application IHC, IHC (p), FACS
Validations
Cat. No. ABIN1840980
Quantity 400 μL
Datasheet Datasheet
Reactivity Guinea Pig, Horse, Human, Mouse, Rat
Application WB, IP, ChIP, PLA
Validations
Cat. No. ABIN1908616
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Horse, Human, Mouse, Rabbit
Application WB, IP
Validations
Cat. No. ABIN1908615
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
Cat. No. ABIN2624628
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN2624630
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
Cat. No. ABIN1908617
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
Cat. No. ABIN1908619
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
Cat. No. ABIN1908620
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
Cat. No. ABIN1908621
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
Cat. No. ABIN1908622
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN1908624
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN1908626
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN1908627
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN1908628
Quantity 200 μL
Datasheet Datasheet

Latest Publications for our Lysine (K)-Specific Methyltransferase 2A 抗体

Luo, Zhu, Xu, Lai, Yan, Guo, Fung, Zeisig, Cui, Zha, Cogle, Wang, Xu, Yang, Li, So, Qiu, Xu, Huang: "HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice." in: Cancer cell, Vol. 36, Issue 6, pp. 645-659.e8, (2019) (PubMed).

Barrett, Malouf, Kapeni, Bacon, Giotopoulos, Jacobsen, Huntly, Ottersbach: "Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development." in: Cell reports, Vol. 16, Issue 4, pp. 1039-54, (2016) (PubMed).

Schaller, Ito, Allen, Kroetz, Kittan, Ptaschinski, Cavassani, Carson, Godessart, Grembecka, Cierpicki, Dou, Kunkel: "Epigenetic regulation of IL-12-dependent T cell proliferation." in: Journal of leukocyte biology, Vol. 98, Issue 4, pp. 601-13, (2015) (PubMed).

Zhang, Liu, Medrzycki, Cao, Fan: "Reduction of Hox gene expression by histone H1 depletion." in: PLoS ONE, Vol. 7, Issue 6, pp. e38829, (2012) (PubMed).

Akalin, Garrett-Bakelman, Kormaksson, Busuttil, Zhang, Khrebtukova, Milne, Huang, Biswas, Hess, Allis, Roeder, Valk, Löwenberg, Delwel, Fernandez, Paietta, Tallman, Schroth, Mason, Melnick, Figueroa: "Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia." in: PLoS genetics, Vol. 8, Issue 6, pp. e1002781, (2012) (PubMed).

Liu, Qu, Chen, Liao, Cheng, Shao, Zenke, Keating, Zhao: "Mesenchymal stem/stromal cells induce the generation of novel IL-10-dependent regulatory dendritic cells by SOCS3 activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 3, pp. 1182-92, (2012) (PubMed).

Shore, Kabotyanski, Roarty, Smith, Zhang, Creighton, Dinger, Rosen: "Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation." in: PLoS genetics, Vol. 8, Issue 7, pp. e1002840, (2012) (PubMed).

Wang, Wu, Mi, He, Wu, Dong, Luo, Mattison, Kaberlein, Prabhakar, Ji, Thirman: "MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome." in: Blood, Vol. 117, Issue 25, pp. 6895-905, (2011) (PubMed).

Park, Yoon, Park, Kim, Um: "Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}." in: The Journal of biological chemistry, Vol. 286, Issue 2, pp. 1354-63, (2011) (PubMed).

Gialitakis, Arampatzi, Makatounakis, Papamatheakis: "Gamma interferon-dependent transcriptional memory via relocalization of a gene locus to PML nuclear bodies." in: Molecular and cellular biology, Vol. 30, Issue 8, pp. 2046-56, (2010) (PubMed).

Aliases for Lysine (K)-Specific Methyltransferase 2A 抗体

lysine (K)-specific methyltransferase 2A (Kmt2a) 抗体
6430520K01 抗体
ALL-1 抗体
All1 抗体
Cxxc7 抗体
HRX 抗体
HTRX1 抗体
mKIAA4050 抗体
Mll 抗体
Mll1 抗体
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