LRRK2 产品
(Leucine-Rich Repeat Kinase 2 (LRRK2))
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This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008].
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LRRK2 抗体
High quality antibodies with extensive validation data.
Recommended LRRK2 抗体
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Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (5)
Cat. No.
ABIN3031607
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF
Validations
- (5)
Cat. No.
ABIN3031610
Quantity
0.4 mL
Datasheet
Datasheet
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Human
Application
WB, ELISA, IHC
Validations
- (5)
Cat. No.
ABIN3028794
Quantity
0.4 mL
Datasheet
Datasheet
Recommended LRRK2 蛋白
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Source
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Human
Source
Escherichia coli (E. coli)
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Cat. No.
ABIN7399454
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7496521
Quantity
200 μg
Datasheet
Datasheet
Latest Publications for our LRRK2 Products
: "LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease." in: Human molecular genetics, (2019) (PubMed).: "LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia." in: PLoS ONE, Vol. 14, Issue 1, pp. e0210248, (2019) (PubMed).
: "LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT1A Receptor Upregulation in Mice." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 38, Issue 7, pp. 1611-1621, (2019) (PubMed).
: "Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models." in: Cell metabolism, Vol. 30, Issue 6, pp. 1131-1140.e7, (2019) (PubMed).
: "Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations." in: Acta neuropathologica communications, Vol. 6, Issue 1, pp. 105, (2018) (PubMed).
: "Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1." in: Nature communications, Vol. 7, pp. 11792, (2016) (PubMed).
: "Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons." in: Journal of neuroinflammation, Vol. 13, Issue 1, pp. 295, (2016) (PubMed).
: "LRRK2 contributes to monocyte dysregulation in Parkinson's disease." in: Acta neuropathologica communications, Vol. 4, Issue 1, pp. 123, (2016) (PubMed).
: "Cerebral potential biomarkers discovery and metabolic pathways analysis of ?-synucleinopathies and the dual effects of Acanthopanax senticosus Harms on central nervous system through metabolomics ..." in: Journal of ethnopharmacology, Vol. 163, pp. 264-72, (2015) (PubMed).
: "Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways." in: Journal of neurochemistry, Vol. 131, Issue 2, pp. 239-50, (2015) (PubMed).
Synonyms and alternative names related to LRRK2
leucine-rich repeat kinase 2 (lrrk2), leucine rich repeat kinase 2 (LRRK2), leucine-rich repeat kinase 2 (Lrrk2), 4921513O20Rik, 9330188B09Rik, AURA17, AW561911, cI-46, D630001M17Rik, DARDARIN, Gm927, LRRK2, PARK8, RIPK7, ROCO2Protein level used designations for LRRK2
- leucine-rich repeat serine/threonine-protein kinase 2
- leucine-rich repeat kinase 2
- leucine-rich repeat serine/threonine-protein kinase 2-like
- augmented in rheumatoid arthritis 17
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