LOX 产品
(Lysyl Oxidase (LOX))
Categories
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010].
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Featured LOX Categories
LOX 抗体
High quality antibodies with extensive validation data.
LOX ELISA试剂盒
Reliable ELISA kits for a wide range of species.
LOX 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LOX 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IP
Validations
- (7)
Cat. No.
ABIN7435016
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Dog, Human, Rat
Application
WB, IHC, FACS, IF, IHC (p)
Validations
- (7)
Cat. No.
ABIN1491218
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP
Validations
- (4)
Cat. No.
ABIN7268347
Quantity
100 μL
Datasheet
Datasheet
Recommended LOX ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (8)
- (1)
Cat. No.
ABIN6957599
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6957600
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6957601
Quantity
96 tests
Datasheet
Datasheet
Recommended LOX 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (12)
- (1)
Cat. No.
ABIN2712316
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123817
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7413259
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our LOX Products
: "Eliminating Regurgitation Reduces Fibrotic Remodeling of Functional Mitral Regurgitation Conditioned Valves." in: Annals of biomedical engineering, Vol. 46, Issue 5, pp. 670-683, (2019) (PubMed).: "LOX-catalyzed collagen stabilization is a proximal cause for intrinsic resistance to chemotherapy." in: Oncogene, Vol. 37, Issue 36, pp. 4921-4940, (2019) (PubMed).
: "TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro." in: Connective tissue research, Vol. 60, Issue 5, pp. 495-506, (2019) (PubMed).
: "Downregulation of lysyl oxidase and lysyl oxidase-like protein 2 suppressed the migration and invasion of trophoblasts by activating the TGF-β/collagen pathway in preeclampsia." in: Experimental & molecular medicine, Vol. 51, Issue 2, pp. 20, (2019) (PubMed).
: "Lysyl oxidase-a possible role in systemic sclerosis-associated pulmonary hypertension: a multicentre study. ..." in: Rheumatology (Oxford, England), (2019) (PubMed).
: "LOX and ACSL5 as potential relapse markers for pancreatic cancer patients." in: Cancer biology & therapy, Vol. 20, Issue 6, pp. 787-798, (2019) (PubMed).
: "Decreased lysyl oxidase level protects against development of retinal vascular lesions in diabetic retinopathy." in: Experimental eye research, Vol. 184, pp. 221-226, (2019) (PubMed).
: "Cyclophilin B control of lysine post-translational modifications of skin type I collagen." in: PLoS genetics, Vol. 15, Issue 6, pp. e1008196, (2019) (PubMed).
: "Type III collagen is a key regulator of the collagen fibrillar structure and biomechanics of articular cartilage and meniscus." in: Matrix biology : journal of the International Society for Matrix Biology, (2019) (PubMed).
: "Lysyl Oxidase Is a Key Player in BRAF/MAPK Pathway-Driven Thyroid Cancer Aggressiveness." in: Thyroid : official journal of the American Thyroid Association, Vol. 29, Issue 1, pp. 79-92, (2019) (PubMed).
Synonyms and alternative names related to LOX
lysyl oxidase (LOX), lysyl oxidase (lox), lysyl oxidase a (loxa), lysyl oxidase L homeolog (lox.L), lysyl oxidase (Lox), AI893619, H-rev142, LOX, lox, MGC146507, Rrg1, TSC-160, Xlox, zgc:77447Protein level used designations for LOX
- lysyl oxidase
- protein-lysine 6-oxidase-like
- protein-lysine 6-oxidase
- ras excision protein
- ras recision gene (rrg)
- Lysyl oxidase (an H-rev gene with its expression down-regulated in HRAS-transformed rat 208F fibroblasts)
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