Low Density Lipoprotein Receptor 产品
(Low Density Lipoprotein Receptor (LDLR))
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The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010].
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Featured Low Density Lipoprotein Receptor Categories
Low Density Lipoprotein Receptor 抗体
High quality antibodies with extensive validation data.
Low Density Lipoprotein Receptor ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Low Density Lipoprotein Receptor 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Low Density Lipoprotein Receptor 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7268296
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (5)
Cat. No.
ABIN5542334
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Hamster, Human, Mouse, Plant, Rat
Application
WB, ELISA, FACS, IF (p), IHC (p)
Validations
- (5)
- (3)
Cat. No.
ABIN672111
Quantity
100 μL
Datasheet
Datasheet
Recommended Low Density Lipoprotein Receptor ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6957532
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968344
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968345
Quantity
96 tests
Datasheet
Datasheet
Recommended Low Density Lipoprotein Receptor 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275138
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275139
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1309277
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Low Density Lipoprotein Receptor Products
: "VEGF-B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol content." in: EMBO reports, Vol. 21, Issue 7, pp. e49343, (2020) (PubMed).: "Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained." in: The Journal of biological chemistry, Vol. 293, Issue 19, pp. 7329-7343, (2019) (PubMed).
: "Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 27, Issue 1, pp. 188-199, (2019) (PubMed).
: "Clinical relevance of cholesterol homeostasis genes in colorectal cancer." in: Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol. 1864, Issue 10, pp. 1314-1327, (2019) (PubMed).
: "Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells." in: Scientific reports, Vol. 9, Issue 1, pp. 6650, (2019) (PubMed).
: "Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr-/-mice." in: Scientific reports, Vol. 7, Issue 1, pp. 17845, (2018) (PubMed).
: "The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins." in: Molecular metabolism, Vol. 16, pp. 88-99, (2018) (PubMed).
: "Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex." in: Scientific reports, Vol. 8, Issue 1, pp. 16845, (2018) (PubMed).
: "Differential Response of B Cells to an Immunogen, a Mitogen and a Chemical Carcinogen in a Mouse Model System" in: Asian Pacific journal of cancer prevention : APJCP, Vol. 19, Issue 1, pp. 81-90, (2018) (PubMed).
: "27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells." in: Neurotoxicology, Vol. 59, pp. 88-97, (2017) (PubMed).
Synonyms and alternative names related to Low Density Lipoprotein Receptor
low density lipoprotein receptor (LDLR), low density lipoprotein receptor (Ldlr), low density lipoprotein receptor a (ldlra), low density lipoprotein receptor S homeolog (ldlr.S), low density lipoprotein receptor L homeolog (ldlr.L), FH, FHC, fhc, Hlb301, LDLA, LDLCQ2, ldlcq2, ldlr, ldlr-a, ldlr-b, ldlr2-a, LDLRA, LDL receptor-2, LDL receptor 1Protein level used designations for Low Density Lipoprotein Receptor
- LDL receptor
- low-density lipoprotein receptor
- low-density lipoprotein receptor class A domain-containing protein 3
- low density lipoprotein receptor (familial hypercholesterolemia)
- LDL receptor 2
- low density lipoprotein receptor-2
- low-density lipoprotein receptor 2
- LDL receptor-1
- low-density lipoprotein receptor 1
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