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LIN28A 抗体

(Lin-28 Homolog A (C. Elegans) (LIN28A))

Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).

recommended

LIN28A 抗体 (AA 108-138) (ABIN655156)

LIN28A 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB14827 unconjugated

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recommended

LIN28A 抗体 (N-Term) (ABIN6741558)

LIN28A 适用: 人, Cow, 犬, Pig, 绵羊 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

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recommended

LIN28A 抗体 (AA 93-209) (ABIN968936)

LIN28A 适用: 人 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 6D1F9 unconjugated

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LIN28A 抗体 by 适用

Find LIN28A 抗体 for a variety of species such as anti-Human LIN28A, anti-Mouse LIN28A, anti-Rat LIN28A. The species listed below are among those available. Click on a link to go to the corresponding products.

LIN28A 抗体 by 应用范围

Find LIN28A 抗体 validated for a specific application such as WB, ELISA, IF, IHC. Some of the available applications are listed below. Click on a link to go to the corresponding products.

LIN28A 抗体 by 抗体来源

Find LIN28A 抗体 with a specific 抗体来源. The 抗体来源 listed below are among those available. Click on a link to go to the corresponding products.

LIN28A 抗体 by 抗原表位

Find LIN28A 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

LIN28A 抗体 by 克隆形成能力

Find available monoclonal or polyclonal LIN28A 抗体. Click on a link to go to the corresponding products.

LIN28A 抗体 by 克隆

Find LIN28A 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

LIN28A 抗体 by 标记

Find LIN28A 抗体 with a specific conjugate such as Biotin, FITC, Alexa Fluor 488. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular LIN28A 抗体

Product

Reactivity

Application

Validations

Cat. No.

Quantity

Datasheet

anti-LIN28A 抗体 (AA 108-138)

Reactivity Human, Mouse

Application WB, IF, FACS, IHC (p)

Validations

Cat. No. ABIN655156

Quantity 400 μL

Datasheet Datasheet

anti-LIN28A 抗体 (N-Term)

Reactivity Cow, Dog, Human, Pig, Sheep

Application WB, IHC, IHC (p)

Validations

Cat. No. ABIN6741558

Quantity 100 μL

Datasheet Datasheet

anti-LIN28A 抗体 (AA 93-209)

Reactivity Human

Application WB, ELISA, ICC

Validations

Cat. No. ABIN968936

Quantity 100 μL

Datasheet Datasheet

anti-LIN28A 抗体 (AA 108-138)

Reactivity Human, Mouse

Application WB, ELISA, IF, IHC, FACS

Validations

Cat. No. ABIN3031626

Quantity 0.4 mL

Datasheet Datasheet

anti-LIN28A 抗体 (AA 1-209)

Reactivity Human

Application ELISA, IF, IHC

Validations

Cat. No. ABIN7165746

Quantity 100 μg

Datasheet Datasheet

anti-LIN28A 抗体 (C-Term)

Reactivity Human

Application WB, IHC (p)

Validations

Cat. No. ABIN6243718

Quantity 400 μL

Datasheet Datasheet

anti-LIN28A 抗体 (C-Term)

Reactivity Human, Mouse

Application WB

Validations

Cat. No. ABIN6243717

Quantity 400 μL

Datasheet Datasheet

anti-LIN28A 抗体 (C-Term)

Reactivity Human, Mouse

Application WB, IF, ICC

Validations

Cat. No. ABIN6972290

Quantity 100 μL

Datasheet Datasheet

anti-LIN28A 抗体 (AA 1-209)

Reactivity Human

Application WB, IP

Validations

Cat. No. ABIN949650

Quantity 100 μL

Datasheet Datasheet

anti-LIN28A 抗体 (AA 1-209)

Reactivity Human

Application WB, IF

Validations

Cat. No. ABIN529026

Quantity 50 μg

Datasheet Datasheet

anti-LIN28A 抗体 (AA 142-209)

Reactivity Human

Application WB, IF, IHC

Validations

Cat. No. ABIN6143238

Quantity 100 μL

Datasheet Datasheet

anti-LIN28A 抗体

Reactivity Human

Application WB, IF, IHC (p)

Validations

Cat. No. ABIN387790

Quantity 400 μL

Datasheet Datasheet

anti-LIN28A 抗体 (pSer134)

Reactivity Human

Application ELISA, IF, DB

Validations

Cat. No. ABIN3028806

Quantity 0.4 mL

Datasheet Datasheet

anti-LIN28A 抗体 (Middle Region)

Reactivity Human, Mouse

Application WB, FACS, IHC (p), EIA

Validations

Cat. No. ABIN953174

Quantity 0.4 mL

Datasheet Datasheet

anti-LIN28A 抗体 (AA 65-160)

Reactivity Human, Rat

Application WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)

Validations

Cat. No. ABIN1387887

Quantity 100 μL

Datasheet Datasheet

Latest Publications for our LIN28A 抗体

Wang, Wan, Xiong, Feng, Wu: "Cancer stem-like cells can be induced through dedifferentiation under hypoxic conditions in glioma, hepatoma and lung cancer." in: Cell death discovery, Vol. 3, pp. 16105, (2017) (PubMed).

Amen, Ruiz-Garzon, Shi, Subramanian, Pham, Meffert: "A Rapid Induction Mechanism for Lin28a in Trophic Responses." in: Molecular cell, Vol. 65, Issue 3, pp. 490-503.e7, (2017) (PubMed).

Boj, Hwang, Baker, Chio, Engle, Corbo, Jager, Ponz-Sarvise, Tiriac, Spector, Gracanin, Oni, Yu, van Boxtel, Huch, Rivera, Wilson, Feigin, Öhlund, Handly-Santana, Ardito-Abraham, Ludwig, Elyada et al.: "Organoid models of human and mouse ductal pancreatic cancer. ..." in: Cell, Vol. 160, Issue 1-2, pp. 324-38, (2015) (PubMed).

Gerecht-Nir, Dazard, Golan-Mashiach, Osenberg, Botvinnik, Amariglio, Domany, Rechavi, Givol, Itskovitz-Eldor: "Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 232, Issue 2, pp. 487-97, (2005) (PubMed).

Wu, Belasco: "Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells." in: Molecular and cellular biology, Vol. 25, Issue 21, pp. 9198-208, (2005) (PubMed).

Aliases for LIN28A 抗体

lin-28 homolog A (LIN28A) 抗体
lin-28 homolog A (C. elegans) (Lin28a) 抗体
lin-28 homolog A S homeolog (lin28a.S) 抗体
lin-28 homolog A (C. elegans) (lin28a) 抗体
lin-28 homolog A (Lin28a) 抗体
lin-28 homolog A (lin28a) 抗体
AL024421 抗体
CSDD1 抗体
csdd1 抗体
ENSMUSG00000070700 抗体
Gm10299 抗体
LIN-28 抗体
Lin-28 抗体
lin-28 抗体
lin-28A 抗体
LIN28 抗体
Lin28 抗体
lin28 抗体
RGD1566408 抗体
sb:cb650 抗体
Tex17 抗体
ZCCHC1 抗体
zcchc1 抗体
zgc:55584 抗体

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LIN28A 抗体 by 克隆形成能力

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Popular LIN28A 抗体

Latest Publications for our LIN28A 抗体

Aliases for LIN28A 抗体

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