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Leptin Receptor 产品

(Leptin Receptor (LEPR))
The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010].

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Featured Leptin Receptor Categories

Leptin Receptor 抗体

High quality antibodies with extensive validation data.

Leptin Receptor ELISA试剂盒

Reliable ELISA kits for a wide range of species.

Leptin Receptor 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Leptin Receptor 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Pig, Rat
Application WB, ELISA, FACS, IF (p), IHC (p), IF (cc), IHC (fro)
Validations
  • (6)
Cat. No. ABIN725060
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
  • (7)
Cat. No. ABIN7430873
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7430876
Quantity 100 μL
Datasheet Datasheet

Recommended Leptin Receptor ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6963259
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6957442
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6963054
Quantity 96 tests
Datasheet Datasheet

Recommended Leptin Receptor 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Human Cells
Validations
  • (1)
Cat. No. ABIN7319902
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7275141
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Human Cells
Validations
  • (1)
Cat. No. ABIN7320922
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our Leptin Receptor Products

Lewandowski, Biesiada, Grzesiak, Sakowicz: "C-Peptide and leptin system in dichorionic, small and appropriate for gestational age twins-possible link to metabolic programming?" in: Nutrition & diabetes, Vol. 10, Issue 1, pp. 29, (2020) (PubMed).

Kesić, Baković, Horvatiček, Proust, Štefulj, Čičin-Šain: "Constitutionally High Serotonin Tone Favors Obesity: Study on Rat Sublines With Altered Serotonin Homeostasis." in: Frontiers in neuroscience, Vol. 14, pp. 219, (2020) (PubMed).

Balzano, De Grandis, Vu Manh, Chasson, Bardin, Farina, Sergé, Bidaut, Charbord, Hérault, Bailly, Cartier-Michaud, Boned, Dalod, Duprez, Genever, Coles, Bajenoff, Xerri, Aurrand-Lions, Schiff, Mancini: "Nidogen-1 Contributes to the Interaction Network Involved in Pro-B Cell Retention in the Peri-sinusoidal Hematopoietic Stem Cell Niche." in: Cell reports, Vol. 26, Issue 12, pp. 3257-3271.e8, (2019) (PubMed).

Frisch, Hoffman, Latchney, LaMere, Myers, Ashton, Li, Saunders, Palis, Perkins, McCabe, Smith, McGrath, Rivera-Escalera, McDavid, Liesveld, Korshunov, Elliott, MacNamara, Becker, Calvi: "Aged marrow macrophages expand platelet-biased hematopoietic stem cells via Interleukin1B." in: JCI insight, Vol. 5, (2019) (PubMed).

Song, Li, Yang, Ning, Zhen, Wu, Zheng, Zhang, Lin, Xie, Peng: "Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow." in: Cell death & disease, Vol. 10, Issue 5, pp. 336, (2019) (PubMed).

Zhao, Tao, Venkatraman, Li, Smith, Unruh, Chen, Ward, Qian, Perry, Marshall, Wang, He, Li: "N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells." in: Cell reports, Vol. 26, Issue 3, pp. 652-669.e6, (2019) (PubMed).

Piattini, Le Foll, Kisielow, Rosenwald, Nielsen, Lutz, Schneider, Kopf: "A spontaneous leptin receptor point mutation causes obesity and differentially affects leptin signaling in hypothalamic nuclei resulting in metabolic dysfunctions distinct from db/db mice." in: Molecular metabolism, Vol. 25, pp. 131-141, (2019) (PubMed).

Yamada, Odamaki, Araki, Watanabe, Matsuo, Uchida, Kato, Ozaki-Masuzawa, Takenaka: "Dietary protein restriction increases hepatic leptin receptor mRNA and plasma soluble leptin receptor in male rodents." in: PLoS ONE, Vol. 14, Issue 7, pp. e0219603, (2019) (PubMed).

Bähr, Jahn, Zipprich, Pahlow, Spielmann, Kielstein: "Impaired natural killer cell subset phenotypes in human obesity." in: Immunologic research, Vol. 66, Issue 2, pp. 234-244, (2019) (PubMed).

Gao, Deng, Chai, Chen, Hu, Wang, Zhu, Cao, Ni, Wan, Yang, Luo, Cao: "Macrophage-lineage TRAP+ cells recruit periosteum-derived cells for periosteal osteogenesis and regeneration." in: The Journal of clinical investigation, Vol. 130, pp. 2578-2594, (2019) (PubMed).

Synonyms and alternative names related to Leptin Receptor

leptin receptor (LEPR), leptin receptor (lepr), leptin receptor (Lepr), leptin receptor S homeolog (lepr.S), CD295, cd295, db, diabetes, Fa, LEP-R, lepr, Leprb, LEPRD, LEPROT, Modb1, OB-R, Ob-R, ob-rb, OB-RGRP, Ob-RM, obese-like, obl, OBR, obr, Obr, ObRb

Protein level used designations for Leptin Receptor

  • OB receptor
  • huB219
  • LEP-R
  • Leptin receptor (fatty)
  • OB-R
  • B219
  • leptin receptor gene-related protein
  • cytokine receptor
  • leptin receptor long insert isoform
  • leptin receptor
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