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LECT1 产品

(Leukocyte Cell Derived Chemotaxin 1 (LECT1))

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This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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Featured LECT1 Categories

LECT1 抗体

High quality antibodies with extensive validation data.

LECT1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

LECT1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended LECT1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (6)
Cat. No. ABIN7435004
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (2)
Cat. No. ABIN524453
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (3)
Cat. No. ABIN389196
Quantity 400 μL
Datasheet Datasheet

Recommended LECT1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6957464
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957465
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1140560
Quantity 96 tests
Datasheet Datasheet

Recommended LECT1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309288
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7396529
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7396526
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our LECT1 Products

Fujii, Furumatsu, Yokoyama, Kanazawa, Kajiki, Abe, Ozaki: "Chondromodulin-I derived from the inner meniscus prevents endothelial cell proliferation." in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Vol. 31, Issue 4, pp. 538-43, (2013) (PubMed).

Aoyama, Okamoto, Kohno, Fukiage, Otsuka, Furu, Ito, Jin, Nagayama, Nakayama, Nakamura, Toguchida: "Cell-specific epigenetic regulation of ChM-I gene expression: crosstalk between DNA methylation and histone acetylation." in: Biochemical and biophysical research communications, Vol. 365, Issue 1, pp. 124-30, (2007) (PubMed).

Yoshioka, Yuasa, Matsumura, Kimura, Shiomi, Kimura, Shukunami, Okada, Mukai, Shin, Yozu, Sata, Ogawa, Hiraki, Fukuda: "Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis." in: Nature medicine, Vol. 12, Issue 10, pp. 1151-9, (2006) (PubMed).

Aoyama, Okamoto, Nagayama, Nishijo, Ishibe, Yasura, Nakayama, Nakamura, Toguchida: "Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3." in: The Journal of biological chemistry, Vol. 279, Issue 27, pp. 28789-97, (2004) (PubMed).

Lin, Wang, Wang: "Chondromodulin‑I suppresses tumorigenesis of human osteosarcoma cells." in: Molecular medicine reports, Vol. 16, Issue 6, pp. 8542-8548 (PubMed).

Synonyms and alternative names related to LECT1

chondromodulin L homeolog (cnmd.L), leukocyte cell derived chemotaxin 1 (lect1), chondromodulin (CNMD), chondromodulin (cnmd), chondromodulin (Cnmd), bricd3, BRICD3, Bricd3, Chm-1, chm-i, CHM-I, ChM-I, chm1, CHM1, chondromodulin-I, Lect1, MGC53801, MGC82444, MYETS1

Protein level used designations for LECT1

  • leukocyte cell derived chemotaxin 1
  • chondromodulin-I
  • chondromodulin-1-like
  • chondromodulin-1
  • leukocyte cell-derived chemotaxin 1
  • BRICHOS domain containing 3
  • chondromodulin I
  • multiple myeloma tumor suppressor 1
  • SCGP
  • small cartilage-derived glycoprotein
  • Chondromodulin 1
  • chM-I
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