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Low Density Lipoprotein Receptor 产品

(Low Density Lipoprotein Receptor (LDLR))

Categories

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010].

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Featured Low Density Lipoprotein Receptor Categories

Low Density Lipoprotein Receptor 抗体

High quality antibodies with extensive validation data.

Low Density Lipoprotein Receptor ELISA试剂盒

Reliable ELISA kits for a wide range of species.

Low Density Lipoprotein Receptor 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Low Density Lipoprotein Receptor 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (5)
Cat. No. ABIN7268296
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, FACS, ICC
Validations
  • (5)
Cat. No. ABIN5542334
Quantity 100 μL
Datasheet Datasheet
Reactivity Hamster, Human, Mouse, Plant, Rat
Application WB, ELISA, FACS, IF (p), IHC (p)
Validations
  • (5)
  • (3)
Cat. No. ABIN672111
Quantity 100 μL
Datasheet Datasheet

Recommended Low Density Lipoprotein Receptor ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6957532
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968344
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968345
Quantity 96 tests
Datasheet Datasheet

Recommended Low Density Lipoprotein Receptor 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275138
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
Cat. No. ABIN7275139
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1309277
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our Low Density Lipoprotein Receptor Products

Moessinger, Nilsson, Muhl, Zeitelhofer, Heller Sahlgren, Skogsberg, Eriksson: "VEGF-B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol content." in: EMBO reports, Vol. 21, Issue 7, pp. e49343, (2020) (PubMed).

Lebeau, Platko, Al-Hashimi, Byun, Lhoták, Holzapfel, Gyulay, Igdoura, Cool, Trigatti, Seidah, Austin: "Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained." in: The Journal of biological chemistry, Vol. 293, Issue 19, pp. 7329-7343, (2019) (PubMed).

Khoshnejad, Patel, Wojtak, Kudchodkar, Humeau, Lyssenko, Rader, Muthumani, Weiner: "Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 27, Issue 1, pp. 188-199, (2019) (PubMed).

Sharma, Gupta, Dahiya, Kumar, Vaiphei, Agnihotri: "Clinical relevance of cholesterol homeostasis genes in colorectal cancer." in: Biochimica et biophysica acta. Molecular and cell biology of lipids, Vol. 1864, Issue 10, pp. 1314-1327, (2019) (PubMed).

Silva, Lütjohann, Hamid, Velasquez, Kerner, Larrazabal, Failing, Hermosilla, Taubert: "Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells." in: Scientific reports, Vol. 9, Issue 1, pp. 6650, (2019) (PubMed).

Xu, Xu, Xu, Yin, Zhang: "Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr-/-mice." in: Scientific reports, Vol. 7, Issue 1, pp. 17845, (2018) (PubMed).

Fischer, Albers, Krott, Hoffzimmer, Heine, Schmale, Scheja, Gordts, Heeren: "The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins." in: Molecular metabolism, Vol. 16, pp. 88-99, (2018) (PubMed).

Riad, Zeng, Weng, Winters, Xu, Makvandi, Metz, Carlin, Mach: "Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex." in: Scientific reports, Vol. 8, Issue 1, pp. 16845, (2018) (PubMed).

Saxena, Kaur, Chandra: "Differential Response of B Cells to an Immunogen, a Mitogen and a Chemical Carcinogen in a Mouse Model System" in: Asian Pacific journal of cancer prevention : APJCP, Vol. 19, Issue 1, pp. 81-90, (2018) (PubMed).

An, Zhang, Yu, Ma, Lu, Liu, Xiao: "27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells." in: Neurotoxicology, Vol. 59, pp. 88-97, (2017) (PubMed).

Synonyms and alternative names related to Low Density Lipoprotein Receptor

low density lipoprotein receptor (LDLR), low density lipoprotein receptor (Ldlr), low density lipoprotein receptor a (ldlra), low density lipoprotein receptor S homeolog (ldlr.S), low density lipoprotein receptor L homeolog (ldlr.L), FH, FHC, fhc, Hlb301, LDLA, LDLCQ2, ldlcq2, ldlr, ldlr-a, ldlr-b, ldlr2-a, LDLRA, LDL receptor-2, LDL receptor 1

Protein level used designations for Low Density Lipoprotein Receptor

  • LDL receptor
  • low-density lipoprotein receptor
  • low-density lipoprotein receptor class A domain-containing protein 3
  • low density lipoprotein receptor (familial hypercholesterolemia)
  • LDL receptor 2
  • low density lipoprotein receptor-2
  • low-density lipoprotein receptor 2
  • LDL receptor-1
  • low-density lipoprotein receptor 1
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