LATS1 抗体
(LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
recommended
recommended
recommended
LATS1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
LATS1 抗体 by 应用范围
Find LATS1 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.
LATS1 抗体 by 抗体来源
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LATS1 抗体 by 克隆形成能力
Find available monoclonal or polyclonal LATS1 抗体. Click on a link to go to the corresponding products.
LATS1 抗体 by 克隆
Find LATS1 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.
Popular LATS1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IP, IF
Validations
- (5)
Cat. No.
ABIN7169059
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN522568
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6262920
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (2)
- (1)
Cat. No.
ABIN872292
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (1)
- (2)
Cat. No.
ABIN391033
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN3031593
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN2566023
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Bat, Cow, Dog, Hamster, Horse, Human, Monkey, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
- (1)
Cat. No.
ABIN6741908
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Horse, Human, Mouse, Rabbit, Rat, Saccharomyces cerevisiae, Sheep, Zebrafish (Danio rerio)
Application
WB
Validations
- (2)
Cat. No.
ABIN2787626
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), EIA
Validations
- (2)
Cat. No.
ABIN359091
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No.
ABIN877417
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN877405
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN877413
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN2803713
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IF (cc), IF (p)
Validations
Cat. No.
ABIN877404
Quantity
100 μL
Datasheet
Datasheet
Latest Publications for our LATS1 抗体
: "STK3/4 Expression Is Regulated in Uterine Endometrial Cells during the Estrous Cycle." in: Cells, Vol. 8, Issue 12, (2020) (PubMed).: "The polarity protein Angiomotin p130 controls dendritic spine maturation." in: The Journal of cell biology, Vol. 217, Issue 2, pp. 715-730, (2018) (PubMed).
: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." in: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).
: "Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 307, Issue 2, pp. G196-204, (2014) (PubMed).
: "YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14." in: Oncogene, Vol. 32, Issue 17, pp. 2220-9, (2013) (PubMed).
: "Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity." in: Cancer research, Vol. 71, Issue 5, pp. 2010-20, (2011) (PubMed).
: "Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development." in: Development (Cambridge, England), Vol. 138, Issue 5, pp. 947-57, (2011) (PubMed).
: "Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse." in: Molecular and cellular biology, Vol. 29, Issue 23, pp. 6309-20, (2009) (PubMed).
: "Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis." in: Blood, Vol. 111, Issue 2, pp. 816-28, (2008) (PubMed).
: "A crucial role of WW45 in developing epithelial tissues in the mouse." in: The EMBO journal, Vol. 27, Issue 8, pp. 1231-42, (2008) (PubMed).
Aliases for LATS1 抗体
large tumor suppressor kinase 1 (LATS1) 抗体large tumor suppressor (Lats1) 抗体
large tumor suppressor kinase 1 (lats1) 抗体
large tumor suppressor kinase 1 (Lats1) 抗体
large tumor suppressor kinase 1 S homeolog (lats1.S) 抗体
AW208599 抗体
Lats 抗体
lats1 抗体
RGD1564085 抗体
si:dkey-181i3.5 抗体
WARTS 抗体
warts 抗体
wts 抗体
wu:fc19a11 抗体
zgc:123219 抗体
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