电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

LARGE 产品

(Like-Glycosyltransferase (LARGE))
This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008].

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured LARGE Categories

LARGE 抗体

High quality antibodies with extensive validation data.

LARGE ELISA试剂盒

Reliable ELISA kits for a wide range of species.

LARGE 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended LARGE 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IP, IHC, ICC
Validations
  • (2)
Cat. No. ABIN7443668
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN6243442
Quantity 50 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB
Validations
  • (1)
Cat. No. ABIN6743423
Quantity 100 μL
Datasheet Datasheet

Recommended LARGE ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1135279
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1135280
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method
Validations
Cat. No. ABIN1135278
Quantity 96 tests
Datasheet Datasheet

Recommended LARGE 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309153
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7417102
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
Cat. No. ABIN3155647
Quantity 0.5 mg
Datasheet Datasheet

Latest Publications for our LARGE Products

Saito, Kanagawa, Ikeda, Hagiwara, Masaki, Ohkuma, Katanosaka, Shimizu, Sonoo, Toda, Matsumura: "Overexpression of LARGE suppresses muscle regeneration via down-regulation of insulin-like growth factor 1 and aggravates muscular dystrophy in mice." in: Human molecular genetics, Vol. 23, Issue 17, pp. 4543-58, (2014) (PubMed).

Reissner, Stahn, Breuer, Klose, Pohlentz, Mormann, Missler: "Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain." in: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27585-603, (2014) (PubMed).

de Bernabé, Inamori, Yoshida-Moriguchi, Weydert, Harper, Willer, Henry, Campbell: "Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11279-84, (2009) (PubMed).

Synonyms and alternative names related to LARGE

LARGE xylosyl- and glucuronyltransferase 1 L homeolog (large1.L), LARGE xylosyl- and glucuronyltransferase 1 (LARGE1), LARGE xylosyl- and glucuronyltransferase 1 (Large1), LARGE xylosyl- and glucuronyltransferase 1 (large1), glycosyltransferase-like protein LARGE1 (LOC100118066), like-glycosyltransferase (LARGE), like-glycosyltransferase (Large), BPFD36, DKFZp459G0120, enr, fg, froggy, Gyltl1a, gyltl1b, gyltl1b-b, Mbp-1, Mbp1, mdc1d, MDC1D, MDDGA6, MDDGB6, mKIAA0609, myd, NV15834

Protein level used designations for LARGE

  • glycosyltransferase-like 1B
  • glycosyltransferase-like 1B-B
  • glycosyltransferase-like protein LARGE2-B
  • acetylglucosaminyltransferase-like 1A
  • acetylglucosaminyltransferase-like protein
  • glycosyltransferase-like protein LARGE1
  • like-acetylglucosaminyltransferase
  • myodystrophy
  • glycosyltransferase-like 1A
  • like-glycosyltransferase
  • glycosyltransferase-like protein LARGE1-like
  • eosinophil granule major basic protein 1
  • prepro major basic protein 1
You are here:
客服