LARGE 产品
(Like-Glycosyltransferase (LARGE))
Categories
This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008].
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Featured LARGE Categories
LARGE 抗体
High quality antibodies with extensive validation data.
LARGE ELISA试剂盒
Reliable ELISA kits for a wide range of species.
LARGE 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LARGE 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IP, IHC, ICC
Validations
- (2)
Cat. No.
ABIN7443668
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN6243442
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB
Validations
- (1)
Cat. No.
ABIN6743423
Quantity
100 μL
Datasheet
Datasheet
Recommended LARGE ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1135279
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1135280
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Validations
Cat. No.
ABIN1135278
Quantity
96 tests
Datasheet
Datasheet
Recommended LARGE 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309153
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7417102
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Guinea Pig
Source
Yeast
Validations
Cat. No.
ABIN1660890
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our LARGE Products
: "Overexpression of LARGE suppresses muscle regeneration via down-regulation of insulin-like growth factor 1 and aggravates muscular dystrophy in mice." in: Human molecular genetics, Vol. 23, Issue 17, pp. 4543-58, (2014) (PubMed).: "Dystroglycan binding to α-neurexin competes with neurexophilin-1 and neuroligin in the brain." in: The Journal of biological chemistry, Vol. 289, Issue 40, pp. 27585-603, (2014) (PubMed).
: "Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE." in: The Journal of biological chemistry, Vol. 284, Issue 17, pp. 11279-84, (2009) (PubMed).
Synonyms and alternative names related to LARGE
LARGE xylosyl- and glucuronyltransferase 1 L homeolog (large1.L), LARGE xylosyl- and glucuronyltransferase 1 (LARGE1), LARGE xylosyl- and glucuronyltransferase 1 (Large1), LARGE xylosyl- and glucuronyltransferase 1 (large1), glycosyltransferase-like protein LARGE1 (LOC100118066), like-glycosyltransferase (LARGE), like-glycosyltransferase (Large), BPFD36, DKFZp459G0120, enr, fg, froggy, Gyltl1a, gyltl1b, gyltl1b-b, Mbp-1, Mbp1, mdc1d, MDC1D, MDDGA6, MDDGB6, mKIAA0609, myd, NV15834Protein level used designations for LARGE
- glycosyltransferase-like 1B
- glycosyltransferase-like 1B-B
- glycosyltransferase-like protein LARGE2-B
- acetylglucosaminyltransferase-like 1A
- acetylglucosaminyltransferase-like protein
- glycosyltransferase-like protein LARGE1
- like-acetylglucosaminyltransferase
- myodystrophy
- glycosyltransferase-like 1A
- like-glycosyltransferase
- glycosyltransferase-like protein LARGE1-like
- eosinophil granule major basic protein 1
- prepro major basic protein 1
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