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KRIT1 产品

(KRIT1, Ankyrin Repeat Containing (KRIT1))

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This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009].

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Featured KRIT1 Categories

KRIT1 抗体

High quality antibodies with extensive validation data.

KRIT1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended KRIT1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
  • (3)
Cat. No. ABIN1387606
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, IHC
Validations
  • (2)
Cat. No. ABIN7157699
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN560207
Quantity 50 μL
Datasheet Datasheet

Recommended KRIT1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123697
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308947
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308946
Quantity 25 μg
Datasheet Datasheet

Latest Publications for our KRIT1 Products

Zawistowski, Stalheim, Uhlik, Abell, Ancrile, Johnson, Marchuk: "CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis." in: Human molecular genetics, Vol. 14, Issue 17, pp. 2521-31, (2005) (PubMed).

Synonyms and alternative names related to KRIT1

KRIT1, ankyrin repeat containing (KRIT1), KRIT1, ankyrin repeat containing (Krit1), KRIT1, ankyrin repeat containing (krit1), 2010007K12Rik, A630036P20Rik, AA432855, AI450393, AI643869, BB155247, BB235701, CAM, CCM1, Ccm1, fb36f07, krit1, RGD1305929, san, santa, wu:fb36f07, zgc:63585

Protein level used designations for KRIT1

  • ankyrin repeat-containing protein Krit1
  • cerebral cavernous malformations 1 protein
  • krev interaction trapped 1
  • krev interaction trapped protein 1
  • cerebral cavernous malformations 1 protein homolog
  • Krev interaction trapped protein 1
  • ccm1
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