KPNB1 抗体
(Karyopherin (Importin) beta 1 (KPNB1))
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013].
recommended
Verified KPNB1 适用: 人, 大鼠 WB, ELISA, IHC, FACS, IF 宿主: 山羊 Polyclonal unconjugated
recommended
recommended
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Latest Publications for our KPNB1 抗体
: "Antiviral activity of a purine synthesis enzyme reveals a key role of deamidation in regulating protein nuclear import." in: Science advances, Vol. 5, Issue 10, pp. eaaw7373, (2019) (PubMed).: "Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 46, pp. 16502-7, (2014) (PubMed).
: "Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1." in: The Journal of biological chemistry, Vol. 281, Issue 30, pp. 20883-90, (2006) (PubMed).
: "Spatial coordination of spindle assembly by chromosome-mediated signaling gradients." in: Science (New York, N.Y.), Vol. 309, Issue 5739, pp. 1373-6, (2005) (PubMed).
: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).
: "Exercise training attenuates coronary smooth muscle phenotypic modulation and nuclear Ca2+ signaling." in: American journal of physiology. Heart and circulatory physiology, Vol. 283, Issue 6, pp. H2397-410, (2002) (PubMed).
: "Role of importin-beta in coupling Ran to downstream targets in microtubule assembly." in: Science (New York, N.Y.), Vol. 291, Issue 5504, pp. 653-6, (2001) (PubMed).
: "The path of RNA through nuclear pores: apparent entry from the sides into specialized pores." in: Journal of cell science, Vol. 113 Pt 2, pp. 291-302, (2000) (PubMed).
: "Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins." in: Cell, Vol. 83, Issue 5, pp. 683-92, (1996) (PubMed).
: "Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 5, pp. 1769-73, (1995) (PubMed).
Aliases for KPNB1 抗体
importin beta-1 subunit (AFUA_1G15720) 抗体importin beta-1 subunit (AOR_1_1974174) 抗体
Importin beta-1 subunit (Bm1_57540) 抗体
importin beta-1 subunit (PMAA_065830) 抗体
importin beta-1 subunit (AFLA_083750) 抗体
importin beta-1 subunit (TSTA_085870) 抗体
importin beta-1 subunit (BDBG_07509) 抗体
importin beta-1 subunit (MCYG_00039) 抗体
karyopherin (importin) beta 1 L homeolog (kpnb1.L) 抗体
importin beta 1 (LOC100533387) 抗体
karyopherin subunit beta 1 (KPNB1) 抗体
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