The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008].
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Yang, Chiang, Chen, Lee, Wu, Tsou, Yang, Chang, Lin: "Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58)." in: Journal of biomedical science, Vol. 22, pp. 33, (2016) (PubMed).