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KPNA2 产品

(Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2))

Categories

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008].

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Featured KPNA2 Categories

KPNA2 抗体

High quality antibodies with extensive validation data.

KPNA2 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

KPNA2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended KPNA2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, IHC, ELISA, ICC, FACS
Validations
  • (8)
Cat. No. ABIN5542626
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA, IF
Validations
  • (4)
Cat. No. ABIN7156118
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Rat
Application WB, IHC, ELISA, IF, FACS
Validations
  • (4)
Cat. No. ABIN185157
Quantity 100 μg
Datasheet Datasheet

Recommended KPNA2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (3)
  • (1)
Cat. No. ABIN6957267
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968099
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN454324
Quantity 96 tests
Datasheet Datasheet

Recommended KPNA2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1308916
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308918
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123665
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our KPNA2 Products

Wang, Yu, Huang, Yi, Cheng, Kao, Lao, Chang: "Association of overexpressed karyopherin alpha 2 with poor survival and its contribution to interleukin-1β-induced matrix metalloproteinase expression in oral cancer." in: Head & neck, Vol. 40, Issue 8, pp. 1719-1733, (2018) (PubMed).

Huang, Zhou, Cao, Lin, Zhang, Huang, Zheng: "KPNA2 is a potential diagnostic serum biomarker for epithelial ovarian cancer and correlates with poor prognosis." in: Tumour biology, Vol. 39, Issue 6, pp. 1010428317706289, (2017) (PubMed).

Ye, Chen, Li, Zhao, He, Zohaib, Song, Deng, Zhang, Chen, Cao: "Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB." in: Journal of virology, Vol. 91, Issue 8, (2017) (PubMed).

Yajima, Wessel: "Essential elements for translation: the germline factor Vasa functions broadly in somatic cells." in: Development (Cambridge, England), Vol. 142, Issue 11, pp. 1960-70, (2015) (PubMed).

Jeong, Kim, Lee, Cha, Khadka, Cho, Chung: "Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation." in: Journal of cell science, Vol. 128, Issue 12, pp. 2287-301, (2015) (PubMed).

Ma, Zhao: "KPNA2 is a promising biomarker candidate for esophageal squamous cell carcinoma and correlates with cell proliferation." in: Oncology reports, Vol. 32, Issue 4, pp. 1631-7, (2014) (PubMed).

Wang, Zhao, Bi, Sun, Liu, Liu: "Tyrosine 132 phosphorylation of influenza A virus M1 protein is crucial for virus replication by controlling the nuclear import of M1." in: Journal of virology, Vol. 87, Issue 11, pp. 6182-91, (2013) (PubMed).

Wang, Wang, Wang, Chen, Wu, Liang, Tsai, Chang, Yu, Yu: "Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome." in: International journal of cancer. Journal international du cancer, Vol. 128, Issue 10, pp. 2364-72, (2011) (PubMed).

Sun, van Koningsbruggen, Long, Straasheijm, Klooster, Jones, Bellini, Levesque, Brieher, van der Maarel, Jones: "Facioscapulohumeral muscular dystrophy region gene 1 is a dynamic RNA-associated and actin-bundling protein." in: Journal of molecular biology, Vol. 411, Issue 2, pp. 397-416, (2011) (PubMed).

Ishiguro, Ando, Maeda, Watanabe, Goto: "Cutting edge: tubulin ? functions as an adaptor in NFAT-importin ? interaction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 5, pp. 2710-3, (2011) (PubMed).

Synonyms and alternative names related to KPNA2

karyopherin subunit alpha 2 (KPNA2), importin subunit alpha-2 (EDI_246290), importin subunit alpha-2 (EDI_335040), Importin subunit alpha-2 (ima2), karyopherin subunit alpha 2 (Kpna2), karyopherin (importin) alpha 2 (Kpna2), karyopherin alpha-2 subunit like L homeolog (kpna2.L), karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (kpna2), 2410044B12Rik, hm:zeh0389, hm:zeh0389r, ima2, importin, IPOA1, ipoa1, kpna2, PTAC58, QIP2, qip2, RCH1, Rch1, rch1, SRP1alpha, srp1alpha, zgc:86945, zgc:113902

Protein level used designations for KPNA2

  • RAG cohort 1
  • RAG cohort protein 1
  • SRP1-alpha
  • importin alpha 1
  • importin alpha 2
  • importin subunit alpha-1
  • importin subunit alpha-2
  • importin-alpha-P1
  • karyopherin subunit alpha-2
  • pendulin
  • Importin subunit alpha-2
  • karyopherin (importin) alpha 2
  • nuclear import protein
  • importin alpha P1
  • m-importin-alpha-P1
  • pore targeting complex 58 kDa subunit
  • karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
  • karyopherin alpha-2 subunit like L homeolog
  • zeh0389
  • zeh0389r
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