KLRK1 抗体
(Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010].
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recommended
KLRK1 适用: 小鼠 WB, FACS, ELISA, IHC (fro), IF (cc), IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
recommended
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Latest Publications for our KLRK1 抗体
: "Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis." in: RNA biology, Vol. 16, Issue 11, pp. 1592-1603, (2019) (PubMed).: "Quantitative and functional analysis of CD69(+) T regulatory lymphocytes in patients with periodontal disease." in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, (2016) (PubMed).
: "Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo." in: PLoS pathogens, Vol. 12, Issue 8, pp. e1005788, (2016) (PubMed).
: "NK cell function is markedly impaired in patients with chronic lymphocytic leukaemia but is preserved in patients with small lymphocytic lymphoma." in: Oncotarget, Vol. 7, Issue 42, pp. 68513-68526, (2016) (PubMed).
: "Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain." in: BMC cancer, Vol. 15, pp. 1011, (2015) (PubMed).
: "Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human ..." in: PLoS pathogens, Vol. 11, Issue 3, pp. e1004671, (2015) (PubMed).
: "Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1." in: PLoS ONE, Vol. 10, Issue 5, pp. e0125544, (2015) (PubMed).
: "Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 98, (2015) (PubMed).
: "NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure." in: PLoS ONE, Vol. 10, Issue 8, pp. e0134568, (2015) (PubMed).
: "Central nervous system acute lymphoblastic leukemia: role of natural killer cells." in: Blood, Vol. 125, Issue 22, pp. 3420-31, (2015) (PubMed).
Aliases for KLRK1 抗体
killer cell lectin like receptor K1 (KLRK1) 抗体killer cell lectin-like receptor subfamily K, member 1 (KLRK1) 抗体
killer cell lectin-like receptor subfamily K, member 1 (Klrk1) 抗体
killer cell lectin like receptor K1 (Klrk1) 抗体
NKG2D protein (NKG2D) 抗体
CD314 抗体
D6H12S2489E 抗体
D12S2489E 抗体
KLR 抗体
KLRK1 抗体
NKG2-D 抗体
NKG2D 抗体
Nkg2d 抗体
Nkrp2 抗体
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