Insulin ELISA 试剂盒
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- 抗原 See all Insulin (INS) ELISA试剂盒
- Insulin (INS)
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适用
- 人
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 检测范围
- 0-200 μIU/mL
- 最低检测浓度
- 0 μIU/mL
- 应用范围
- ELISA
- 原理
- Insulin Microplate Elisa test is intended to be used for the quantitative determination of insulin levels in human serum.
- 样品类型
- Serum
- Analytical Method
- Quantitative
- 灵敏度
- 1.5 μIU/mL
- Featured
- Discover our best selling INS ELISA Kit
- Top Product
- Discover our top product INS ELISA Kit
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Insulin (INS) ELISA Kit
INS 适用: 大鼠 Colorimetric Competition ELISA 123.5 pg/mL - 10000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Insulin (INS) ELISA KitINS 适用: 人 Colorimetric Competition ELISA 61.7 pg/mL - 5000 pg/mL Cell Culture Supernatant, Plasma, Serum
Insulin (INS) ELISA KitINS 适用: 小鼠 Colorimetric Competition ELISA 123.5 pg/mL - 10000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Insulin (INS) ELISA KitINS 适用: 小鼠 Colorimetric Sandwich ELISA 15.6 nlU/mL - 1000 nlU/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Insulin (INS) ELISA KitINS 适用: Pig Colorimetric Competition ELISA 61.7 pg/mL - 5000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Insulin (INS) ELISA KitINS 适用: 大鼠 Colorimetric Sandwich ELISA 78.125 pg/mL - 5000 pg/mL Plasma, Serum, Tissue Homogenate
Insulin (INS) ELISA KitINS 适用: 小鼠 Colorimetric Sandwich ELISA 78.125 pg/mL - 5000 pg/mL Plasma, Serum, Tissue Homogenate
Insulin (INS) ELISA KitINS 适用: 小鼠 Colorimetric Sandwich ELISA 3.13 pg/mL - 200 pg/mL Cell Culture Supernatant, Plasma, Serum
Insulin (INS) ELISA KitINS 适用: 大鼠 Colorimetric Sandwich ELISA 6.25 pg/mL - 400 pg/mL Cell Culture Supernatant, Plasma, Serum
Insulin (INS) ELISA KitINS 适用: Cow Colorimetric Competition ELISA 123.5 pg/mL - 10000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
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- 样本量
- 25 μL
- 实验时间
- < 1 h
- 板类型
- Pre-coated
- 限制
- 仅限研究用
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- 储存条件
- 4 °C
- 有效期
- 12-14 months
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- 抗原 See all Insulin (INS) ELISA试剂盒
- Insulin (INS)
- 别名
- Insulin (INS 产品)
- 背景
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Insulin is the principal hormone responsible for glucose metabolism. It is synthesized in the cells of the islets of Langerhans as the precuror, proinsulin, which is processed to form C-peptide and insulin and both are secreted in equimolar amounts into the portal circulation. The mature insulin molecule comprises two polypeptide chairs, the A chain (21 amino acids) and the B chain (30 amino acids), which are linked by two inter-chain disulphide bridges. There is, in addition, a single intra-chain disulphide bridge in the A chain. The sequence of insulin is highly conserved in mammalian species, and is homologous with the insulin-like growth factors IGF-I and IGF-II. Secretion of insulin is mainly controlled by plasma glucose concentration and the hormones have a number of important metabolic actions. Its principal function is to control the uptake and utilization of glucose in peripheral tissues via the glucose transporter. This and other hypoglycaemic activities, such as the inhibition of hepatic gluconeogenesis and glycogenolysis are counteracted by the hyperglycaemic hormones including glucagons, epinephrine(adrenaline), growth hormone and cortisol. Insulin concentrations are severely reduced in insulin-dependent diabetes (DDM) and some other conditions such as hypopituitarism. Insulin concentrations may be raised in non-insulin- dependant diabetes (NIDDM), obesity, insulinoma and some endocrine dysfunctions such as Cushing?s Syndrome and Acromegaly.
The main clinical utility measurement is in the investigation of hypoglycaemia. Insulin assay have been used in the following applications:
1. To assess the residual cell function, especially in newly diagnosed cases of IDDM.
2. As an aid to the discrimination between IDDM and NIDDM.
3. The diagnosis of insulinoma.
4. In the investigation of the pathophysiology of diabetes mellitus.
Insulin assays are the essentials in various dynamic tests, such as oral of intravenous glucose tolerance tests (OGTT and IVGTT), to determine the insulin response of the pancreas and the degree of insulin resistance. In many applications, insulin measurements may be complicated by cross-reactivity with partially degraded insulin, proinsulin and split forms of proinsulin. Immune complexes of these molecules are essentially problematic in patients who have developed anti-insulin antibodies through animal insulin administration. - 途径
- NF-kappaB Signaling, RTK signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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