DKK4 ELISA 试剂盒
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- 抗原 See all DKK4 ELISA试剂盒
- DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))
- 抗原表位
- AA 19-224
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适用
- 人
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 检测范围
- 156 pg/mL - 10000 pg/mL
- 最低检测浓度
- 156 pg/mL
- 应用范围
- ELISA
- 原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human DKK-4. 96wells/kit, with removable strips.
- 品牌
- PicoKine™
- 样品类型
- Cell Culture Supernatant, Plasma (EDTA - heparin), Serum
- Analytical Method
- Quantitative
- 特异性
- Expression system for standard: NSO, Immunogen sequence: L19-L224
- 灵敏度
- < 10 pg/mL
- 组件
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96-well plate precoated with antibody
lyophilized recombinant standard
biotinylated antibody (dilution 1:100)
Avidin-Biotin-Peroxidase Complex(ABC)(dilution 1:100)
Sample diluent buffer
Antibody diluent buffer
ABC diluent buffer
TMB color developing agent
TMB stop solution
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Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) ELISA Kit
DKK4 适用: 人 Colorimetric Sandwich ELISA 0.156 ng/mL - 10 ng/mL Plasma, Serum, Tissue Homogenate
Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) ELISA KitDKK4 适用: 小鼠 Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Plasma, Serum
Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) ELISA KitDKK4 适用: 小鼠 AA 19-221 Colorimetric Sandwich ELISA
Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) ELISA KitDKK4 适用: 人 Colorimetric Sandwich ELISA 10-10000 pg/mL Cell Culture Supernatant, Plasma, Serum
Dickkopf Homolog 4 (Xenopus Laevis) (DKK4) ELISA KitDKK4 适用: 小鼠 Colorimetric Sandwich ELISA 78-5000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
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- 实验时间
- 15 min
- 板类型
- Pre-coated
- 限制
- 仅限研究用
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- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- 有效期
- 12 months
-
- 抗原 See all DKK4 ELISA试剂盒
- DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))
- 别名
- DKK4 (DKK4 产品)
- 别名
- DKK-4 ELISA Kit, Dkk-4 ELISA Kit, RGD1563172 ELISA Kit, dickkopf WNT signaling pathway inhibitor 4 ELISA Kit, DKK4 ELISA Kit, Dkk4 ELISA Kit
- 背景
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Synonyms: Dickkopf-related protein 4, Dickkopf-4, Dkk-4, hDkk-4, Dickkopf-related protein 4 short form, DKK4
Tissue Specificity: Expressed in cerebellum, T-cells, esophagus and lung.
Background: DKK4 is a membersof the Dickkopf family which are negative regulators of the growth-promoting Wnt / beta-catenin signaling pathway. By FISH, the DKK4 gene was mapped to chromosome 8p11.2-p11.1. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. The expression of DKK4 was significantly reduced in hepatocellular carcinomas (HCCs), particularly in HCCs that showed cytoplasmic beta- catenin accumulation. DKK4 expression was also reduced in HCC cell lines. Ectopic expression of DKK4 in 2 HCC cell lines reduced beta-catenin and cyclin D1 protein levels and attenuated beta-catenin activity in reporter gene assays.
Cellular Localisation: Secreted. - UniProt
- Q9UBT3
- 途径
- WNT signaling
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