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- 抗原 See all KIT ELISA试剂盒
- KIT (Mast/stem Cell Growth Factor Receptor (KIT))
- 抗原表位
- AA 25-527
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适用
- 小鼠
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 应用范围
- ELISA
- 原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse CD117/c-kit
- 品牌
- PicoKine™
- Analytical Method
- Quantitative
- 特异性
- Expression system for standard: NSO, Immunogen sequence: S25-P527
- 交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
- 产品特性
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Tissue Specificity: Isoform 1 and isoform 2 are detected in bone marrow cells, spermatogonia and spermatocytes, but not in round spermatids, elongating spermatids and spermatozoa. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa, but not in spermatogonia and spermatocytes (at protein level). Isoform 1 is widely expressed and detected in fetal liver and bone marrow. Isoform 3 is detected in bone marrow cells enriched in hematopoietic stem cells. .
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Mast/stem Cell Growth Factor Receptor (KIT) ELISA Kit
KIT 适用: 人 Colorimetric Sandwich ELISA 1.56 ng/mL - 100 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Mast/stem Cell Growth Factor Receptor (KIT) ELISA KitKIT 适用: 小鼠 Colorimetric Sandwich ELISA 0.156 ng/mL - 10 ng/mL Plasma, Serum, Tissue Homogenate
Mast/stem Cell Growth Factor Receptor (KIT) ELISA KitKIT 适用: 小鼠 Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Plasma, Serum
Mast/stem Cell Growth Factor Receptor (KIT) ELISA KitKIT 适用: 人 AA 26-520 Colorimetric Sandwich ELISA 156-10000 pg/mL Cell Culture Supernatant, Plasma (EDTA), Plasma (heparin), Serum
Mast/stem Cell Growth Factor Receptor (KIT) ELISA KitKIT 适用: 小鼠 Colorimetric Sandwich ELISA 156-10000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Mast/stem Cell Growth Factor Receptor (KIT) ELISA KitKIT 适用: 人 Colorimetric Sandwich ELISA 780-50000 pg/mL Cell Culture Supernatant, Plasma, Serum
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- 板类型
- Pre-coated
- 限制
- 仅限研究用
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- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- 有效期
- 12 months
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- 抗原 See all KIT ELISA试剂盒
- KIT (Mast/stem Cell Growth Factor Receptor (KIT))
- 别名
- Kit (KIT 产品)
- 别名
- C-Kit ELISA Kit, CD117 ELISA Kit, PBT ELISA Kit, SCFR ELISA Kit, Bs ELISA Kit, Fdc ELISA Kit, Gsfsco1 ELISA Kit, Gsfsco5 ELISA Kit, Gsfsow3 ELISA Kit, SCO1 ELISA Kit, SCO5 ELISA Kit, SOW3 ELISA Kit, Ssm ELISA Kit, Tr-kit ELISA Kit, W ELISA Kit, c-KIT ELISA Kit, c-kit ELISA Kit, MGF ELISA Kit, KIT ELISA Kit, C-KIT ELISA Kit, kit ELISA Kit, receptor ELISA Kit, sparse ELISA Kit, Xkl-1 ELISA Kit, kit-a ELISA Kit, kit-b ELISA Kit, kl1-A ELISA Kit, krk1 ELISA Kit, pbt ELISA Kit, scfr ELISA Kit, KIT proto-oncogene receptor tyrosine kinase ELISA Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a ELISA Kit, KIT proto-oncogene receptor tyrosine kinase S homeolog ELISA Kit, KIT ELISA Kit, Kit ELISA Kit, kita ELISA Kit, kit ELISA Kit, kit.S ELISA Kit
- 背景
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Protein Function: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. .
Background: SCFR(Mast/stem cell growth factor receptor), also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a protein that in humans is encoded by the KIT gene. KIT was first described as the cellular homolog of the feline sarcoma viral oncogene v-kit. The KIT gene is mapped on 4q12. Kit was expressed on the surface of germ cells up to the pachytene stage. Signaling from the KIT receptor tyrosine kinase is essential for primordial germ cell growth both in vivo and in vitro. Determination of the KIT effectors acting in primordial germ cells has been hampered by the lack of effective methods to manipulate easily gene expression in these cells.
Synonyms: Mast/stem cell growth factor receptor Kit,SCFR,2.7.10.1,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,CD117,Kit,Sl,
Full Gene Name: Mast/stem cell growth factor receptor Kit
Cellular Localisation: Isoform 1: Cell membrane, Single-pass type I membrane protein. - UniProt
- P05532
- 途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
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