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- 抗原 See all LGMN ELISA试剂盒
- LGMN (Legumain (LGMN))
- 抗原表位
- AA 18-435
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适用
- 小鼠
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 应用范围
- ELISA
- 原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse Legumain(total)
- 品牌
- PicoKine™
- Analytical Method
- Quantitative
- 特异性
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Expression system for standard: NSO
Immunogen sequence: V18-Y435 - 交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
- 产品特性
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Tissue Specificity: Detected in kidney proximal tubules (at protein level). Ubiquitous. Particularly abundant in kidney and placenta. .
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Legumain (LGMN) ELISA Kit
LGMN 适用: Cow Colorimetric Sandwich ELISA 78.125 pg/mL - 5000 pg/mL Plasma, Serum, Tissue Homogenate
Legumain (LGMN) ELISA KitLGMN 适用: 人 Colorimetric Sandwich ELISA 0.31 ng/mL - 20 ng/mL Cell Lysate, Plasma, Serum, Tissue Homogenate
Legumain (LGMN) ELISA KitLGMN 适用: 小鼠 Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Legumain (LGMN) ELISA KitLGMN 适用: 人 AA 18-433 Colorimetric Sandwich ELISA
Legumain (LGMN) ELISA KitLGMN 适用: 人 Colorimetric Sandwich ELISA 31.2-2000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Legumain (LGMN) ELISA KitLGMN 适用: 小鼠 Colorimetric Sandwich ELISA 31.2-2000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
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- 板类型
- Pre-coated
- 限制
- 仅限研究用
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- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- 有效期
- 12 months
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- 抗原 See all LGMN ELISA试剂盒
- LGMN (Legumain (LGMN))
- 别名
- Lgmn (LGMN 产品)
- 别名
- AEP ELISA Kit, LGMN1 ELISA Kit, PRSC1 ELISA Kit, AI746452 ELISA Kit, AU022324 ELISA Kit, Prsc1 ELISA Kit, MGC64351 ELISA Kit, cb173 ELISA Kit, cb460 ELISA Kit, sb:cb173 ELISA Kit, zgc:76953 ELISA Kit, wu:fa98g05 ELISA Kit, wu:fj92g08 ELISA Kit, lgmn ELISA Kit, MGC88980 ELISA Kit, DELTA VACUOLAR PROCESSING ENZYME ELISA Kit, DELTAVPE ELISA Kit, delta vacuolar processing enzyme ELISA Kit, legumain ELISA Kit, legumain L homeolog ELISA Kit, delta vacuolar processing enzyme ELISA Kit, Legumain ELISA Kit, LGMN ELISA Kit, Lgmn ELISA Kit, lgmn.L ELISA Kit, lgmn ELISA Kit, DELTA-VPE ELISA Kit, MBOO_RS07785 ELISA Kit, Odosp_3582 ELISA Kit, LOC569153 ELISA Kit
- 背景
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Protein Function: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. .
Background: Legumain (asparaginyl endopeptidase, citvac, proteinase B, hemoglobinase, PRSC1 gene product or LGMN (Homo sapiens), vicilin peptidohydrolase, bean endopeptidase) is an enzyme that in humans is encoded by the LGMN gene (previous symbolPRSC1). Using fluorescence in situ hybridization, the LGMN gene was mapped to chromosome 14q32.1. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types.
Synonyms: Legumain,3.4.22.34,Asparaginyl endopeptidase,Protease, cysteine 1,Lgmn,Prsc1,
Full Gene Name: Legumain
Cellular Localisation: Lysosome. - UniProt
- O89017
- 途径
- Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades
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