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PVRL4 ELISA 试剂盒

PVRL4 适用: 人 AA 32-349 Colorimetric Sandwich ELISA
产品编号 ABIN5510701
发货至: 中国
  • 抗原 See all PVRL4 ELISA试剂盒
    PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))
    抗原表位
    AA 32-349
    适用
    • 3
    • 1
    检测方法
    Colorimetric
    实验类型
    Sandwich ELISA
    应用范围
    ELISA
    原理
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Nectin-4
    品牌
    PicoKine™
    Analytical Method
    Quantitative
    特异性
    Expression system for standard: NSO
    Immunogen sequence: G32-S349
    交叉反应 (详细)
    There is no detectable cross-reactivity with other relevant proteins.
    产品特性

    Tissue Specificity: Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma. .

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  • 板类型
    Pre-coated
    限制
    仅限研究用
  • 储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    有效期
    12 months
  • 抗原 See all PVRL4 ELISA试剂盒
    PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))
    别名
    NECTIN4 (PVRL4 产品)
    别名
    PVRL4 ELISA Kit, si:ch211-155e24.1 ELISA Kit, 1200017F15Rik ELISA Kit, Prr4 ELISA Kit, RGD1559826 ELISA Kit, EDSS1 ELISA Kit, LNIR ELISA Kit, PRR4 ELISA Kit, nectin-4 ELISA Kit, nectin cell adhesion molecule 4 ELISA Kit, NECTIN4 ELISA Kit, nectin4 ELISA Kit, Nectin4 ELISA Kit
    背景

    Protein Function: Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.

    Background: Nectin-4, also known as PVRL4, is an adhesion receptor of the immunoglobulin superfamily and functions in cell-cell adhesion. This gene is mapped to chromosome 1q23.3. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

    Synonyms: Nectin-4,Ig superfamily receptor LNIR,Nectin cell adhesion molecule 4 ,Poliovirus receptor-related protein 4,Processed poliovirus receptor-related protein 4,NECTIN4 ,LNIR, PRR4, PVRL4,

    Full Gene Name: Nectin-4

    Cellular Localisation: Cell membrane, Single-pass type I membrane protein . Cell junction, adherens junction . Colocalizes with MLLT4 at cadherin-based adherens junctions (PubMed:11544254).
    UniProt
    Q96NY8
    途径
    Cell-Cell Junction Organization
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