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- 抗原 See all SIGLEC7 ELISA试剂盒
- SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
- 抗原表位
- AA 19-353
- 适用
- 人
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 应用范围
- ELISA
- 原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Siglec-7/CD328
- 品牌
- PicoKine™
- Analytical Method
- Quantitative
- 特异性
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Expression system for standard: NSO
Immunogen sequence: Q19-L353 - 交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
- 产品特性
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Tissue Specificity: Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
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Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7) ELISA Kit
SIGLEC7 适用: 人 Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
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- 板类型
- Pre-coated
- 限制
- 仅限研究用
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- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- 有效期
- 12 months
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- 抗原 See all SIGLEC7 ELISA试剂盒
- SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))
- 别名
- SIGLEC7 (SIGLEC7 产品)
- 别名
- SIGLEC7 ELISA Kit, AIRM1 ELISA Kit, CD328 ELISA Kit, CDw328 ELISA Kit, D-siglec ELISA Kit, QA79 ELISA Kit, SIGLEC-7 ELISA Kit, SIGLEC19P ELISA Kit, SIGLECP2 ELISA Kit, p75 ELISA Kit, p75/AIRM1 ELISA Kit, sialic acid-binding Ig-like lectin 7 ELISA Kit, sialic acid binding Ig like lectin 7 ELISA Kit, LOC468976 ELISA Kit, SIGLEC7 ELISA Kit
- 背景
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Protein Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). .
Background: Sialic acid-binding Ig-like lectin 7, also known as CD328 (cluster of differentiation 328) or AIRM1, is a protein that in humans is encoded by the SIGLEC7 gene. And this gene is mapped to chromosome 19. AIRM1 is a novel member of the sialoadhesin family characterized by 3 immunoglobulin-like extracellular domains (1 N-terminal V type and 2 C2 type) and a classic immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic portion. The highest amino acid sequence similarity found was with the myeloid-specific CD33 Molecule, and similar to other sialoadhesin molecules, AIRM1 appears to mediate sialic acid-dependent ligand recognition.
Synonyms: Sialic acid-binding Ig-like lectin 7,Siglec-7,Adhesion inhibitory receptor molecule 1,AIRM-1,CDw328,D-siglec,QA79 membrane protein,p75,CD328,SIGLEC7,AIRM1,
Full Gene Name: Sialic acid-binding Ig-like lectin 7
Cellular Localisation: Membrane, Single-pass type I membrane protein. - UniProt
- Q9Y286
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