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- SPHK1 (Sphingosine Kinase 1 (SPHK1))
- 抗原表位
- AA 1-384
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适用
- 人
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 应用范围
- ELISA
- 原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human SPHK1
- 品牌
- PicoKine™
- Analytical Method
- Quantitative
- 特异性
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Expression system for standard: NSO
Immunogen sequence: M1-L384 - 交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
- 产品特性
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Tissue Specificity: Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. .
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Sphingosine Kinase 1 (SPHK1) ELISA Kit
SPHK1 适用: 人 Colorimetric Sandwich ELISA 0.31 ng/mL - 20 ng/mL Cell Lysate, Tissue Homogenate
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- 板类型
- Pre-coated
- 限制
- 仅限研究用
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- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- 有效期
- 12 months
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- 抗原 See all SPHK1 ELISA试剂盒
- SPHK1 (Sphingosine Kinase 1 (SPHK1))
- 别名
- SPHK1 (SPHK1 产品)
- 别名
- CG1747 ELISA Kit, Dmel\\CG1747 ELISA Kit, SK1 ELISA Kit, Sphk1 ELISA Kit, SPHK1 ELISA Kit, F18E5.160 ELISA Kit, F18E5_160 ELISA Kit, sphingosine kinase 1 ELISA Kit, SPHK ELISA Kit, 1110006G24Rik ELISA Kit, Sk1 ELISA Kit, Spk1 ELISA Kit, Sphingosine kinase 1 ELISA Kit, sphingosine kinase 1 ELISA Kit, sphingosine kinase 1 L homeolog ELISA Kit, Sk1 ELISA Kit, SPHK1 ELISA Kit, sphk1.L ELISA Kit, Sphk1 ELISA Kit
- 背景
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Protein Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. .
Background: Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene. The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1- phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: Sphingosine kinase 1,SK 1,SPK 1,2.7.1.91,SPHK1,SPHK, SPK,
Full Gene Name: Sphingosine kinase 1
Cellular Localisation: Cytoplasm. Nucleus. Cell membrane. Translocated from the cytoplasm to the plasma membrane in a CIB1-dependent manner. - UniProt
- Q9NYA1
- 途径
- VEGF Signaling
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