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- 抗原 See all TYRO3 ELISA试剂盒
- TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))
- 抗原表位
- AA 31-418
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适用
- 小鼠
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 应用范围
- ELISA
- 原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse DTK/TYRO3
- 品牌
- PicoKine™
- Analytical Method
- Quantitative
- 特异性
- Expression system for standard: NSO, Immunogen sequence: A31-S418
- 交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
- 产品特性
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Tissue Specificity: Abundant in the brain and lower levels in other tissues.
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TYRO3 Protein Tyrosine Kinase (TYRO3) ELISA Kit
TYRO3 适用: 人 Colorimetric Sandwich ELISA 0.45 ng/mL - 30 ng/mL Plasma, Serum, Tissue Homogenate
TYRO3 Protein Tyrosine Kinase (TYRO3) ELISA KitTYRO3 适用: 人 AA 41-428 Colorimetric Sandwich ELISA
TYRO3 Protein Tyrosine Kinase (TYRO3) ELISA KitTYRO3 适用: 小鼠 Colorimetric Sandwich ELISA 0.4-100 ng/mL Cell Culture Supernatant, Plasma, Serum
TYRO3 Protein Tyrosine Kinase (TYRO3) ELISA KitTYRO3 适用: 人 Colorimetric Sandwich ELISA 40-10,000 pg/mL Cell Culture Supernatant, Serum
TYRO3 Protein Tyrosine Kinase (TYRO3) ELISA KitTYRO3 适用: 小鼠 Colorimetric Sandwich ELISA 125-8000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
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- 板类型
- Pre-coated
- 限制
- 仅限研究用
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- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- 有效期
- 12 months
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- 抗原 See all TYRO3 ELISA试剂盒
- TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))
- 别名
- Tyro3 (TYRO3 产品)
- 别名
- TYRO3 ELISA Kit, brt ELISA Kit, byk ELISA Kit, dtk ELISA Kit, rse ELISA Kit, sky ELISA Kit, tif ELISA Kit, Xksy ELISA Kit, MGC145734 ELISA Kit, DKFZp469I0432 ELISA Kit, LOC100231598 ELISA Kit, BYK ELISA Kit, Dtk ELISA Kit, RSE ELISA Kit, Sky ELISA Kit, Tif ELISA Kit, Brt ELISA Kit, REK ELISA Kit, ksy ELISA Kit, xksy ELISA Kit, AI323366 ELISA Kit, Etk-2 ELISA Kit, Rse ELISA Kit, TYRO3 protein tyrosine kinase ELISA Kit, TYRO3 protein tyrosine kinase L homeolog ELISA Kit, TYRO3 protein tyrosine kinase 3 ELISA Kit, TYRO3 ELISA Kit, tyro3 ELISA Kit, Tyro3 ELISA Kit, tyro3.L ELISA Kit
- 背景
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Protein Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. .
Background: Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene. The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses.
Synonyms: Tyrosine-protein kinase receptor TYRO3,2.7.10.1,Etk2/tyro3,TK19-2,Tyrosine-protein kinase DTK,Tyrosine-protein kinase RSE,Tyrosine-protein kinase TIF,Tyro3,Dtk, Rse, Tif,
Full Gene Name: Tyrosine-protein kinase receptor TYRO3
Cellular Localisation: Cell membrane, Single-pass type I membrane protein. - UniProt
- P55144
- 途径
- RTK signaling
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