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- 抗原 See all FcRn ELISA试剂盒
- FcRn (IgG receptor FcRn (FcRn))
- 抗原表位
- AA 22-297
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适用
- 小鼠
- 检测方法
- Colorimetric
- 实验类型
- Sandwich ELISA
- 应用范围
- ELISA
- 原理
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse FCRN/FCGRT
- 品牌
- PicoKine™
- Analytical Method
- Quantitative
- 特异性
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Expression system for standard: NSO
Immunogen sequence: S22-S297 - 交叉反应 （详细）
- There is no detectable cross-reactivity with other relevant proteins.
- 产品特性
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Tissue Specificity: Intestinal epithelium of suckling rodents. Expressed in neonatal intestine and fetal yolk sac.
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IgG receptor FcRn (FcRn) ELISA Kit
FcRn 适用: 人 Colorimetric Sandwich ELISA 0.313 ng/mL - 20 ng/mL Plasma, Serum, Tissue Homogenate
IgG receptor FcRn (FcRn) ELISA KitFcRn 适用: 人 Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Cell Lysate, Tissue Homogenate
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- 板类型
- Pre-coated
- 限制
- 仅限研究用
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- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- 有效期
- 12 months
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- 抗原 See all FcRn ELISA试剂盒
- FcRn (IgG receptor FcRn (FcRn))
- 别名
- Fcgrt (FcRn 产品)
- 别名
- FCRN ELISA Kit, alpha-chain ELISA Kit, FcRn ELISA Kit, Fc fragment of IgG receptor and transporter ELISA Kit, Fc receptor, IgG, alpha chain transporter ELISA Kit, FCGRT ELISA Kit, Fcgrt ELISA Kit
- 背景
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Protein Function: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids.
Background: The neonatal Fc receptor (FcRn), also known as the Brambell receptor, is a protein that in humans is encoded by the FCGRT gene. The neonatal Fc receptor is an Fc receptor which is similar in structure to the MHC class I molecule and also associates with beta-2-microglobulin. It was first discovered in rodents as a unique receptor capable of transporting IgG from mother's milk across the epithelium of newborn rodent's gut into the newborn's bloodstream. Further studies revealed a similar receptor in humans, leading to the naming as a neonatal Fc receptor. In humans, however, it is found in the placenta to help facilitate transport of mother's IgG to the growing fetus and it has also been shown to play a role in monitoring IgG turnover. Neonatal Fc receptor expression is up-regulated by the proinflammatory cytokine,TNF-i±, and down-regulated by IFN-i³.
Synonyms: IgG receptor FcRn large subunit p51,FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor,Fcgrt,Fcrn,
Full Gene Name: IgG receptor FcRn large subunit p51
Cellular Localisation: Cell membrane, Single-pass type I membrane protein. - UniProt
- Q61559
- 途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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