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CD28 ELISA 试剂盒

CD28 适用: 人 AA 19-152 Colorimetric Sandwich ELISA
产品编号 ABIN5510635
发货至: 中国
  • 抗原 See all CD28 ELISA试剂盒
    CD28
    抗原表位
    AA 19-152
    适用
    • 5
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    检测方法
    Colorimetric
    实验类型
    Sandwich ELISA
    应用范围
    ELISA
    原理
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human CD28
    品牌
    PicoKine™
    Analytical Method
    Quantitative
    特异性
    Expression system for standard: NSO
    Immunogen sequence: N19-P152
    交叉反应 (详细)
    There is no detectable cross-reactivity with other relevant proteins.
    产品特性

    Tissue Specificity: Expressed in T-cells and plasma cells, but not in less mature B-cells.

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  • 板类型
    Pre-coated
    限制
    仅限研究用
  • 储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    有效期
    12 months
  • 抗原 See all CD28 ELISA试剂盒
    CD28
    别名
    CD28 (CD28 产品)
    别名
    Tp44 ELISA Kit, CD28RNA ELISA Kit, cd28 ELISA Kit, CD28 molecule ELISA Kit, CD28 antigen ELISA Kit, Cd28 molecule ELISA Kit, CD28 molecule L homeolog ELISA Kit, CD28 ELISA Kit, Cd28 ELISA Kit, cd28.L ELISA Kit
    背景

    Protein Function: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). .

    Background: CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co- stimulatory signals required for T cell activation and survival. T cell stimulation through CD28 in addition to the T-cell receptor (TCR) can provide a potent signal for the production of various interleukins (IL-6 in particular). The CD28 gene is mapped to 2q33-q34. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily.

    Synonyms: T-cell-specific surface glycoprotein CD28,TP44,CD28,CD28,

    Full Gene Name: T-cell-specific surface glycoprotein CD28

    Cellular Localisation: Membrane, Single-pass type I membrane protein.
    UniProt
    P10747
    途径
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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